keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 440.00 | |
10 mg | In stock | $ 648.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,390.00 | |
100 mg | In stock | $ 1,870.00 | |
500 mg | In stock | $ 3,730.00 |
Description | ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities. |
Targets&IC50 | Ba/F3 cells:104.7 nM, ALK (L1196M):41.3 nM, ALK:174 nM, ROS1:530 nM |
In vitro |
(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide (2e) showed impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M with an IC50 value of 41.3 nM.[1]
2e also showed potent inhibitory activity in about 6-fold superior to Crizotinib (IC50: 104.7 nM vs. 643.5 nM) in Ba/F3 cell line harboring ROS1G2032R.[1] |
Synonyms | (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base) |
Molecular Weight | 621.09 |
Formula | C30H36ClF3N6O3 |
CAS No. | T67699L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ALK/ROS1 inhibitor 2e HCL T67699L Apoptosis (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base) inhibitor inhibit