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CM-272

Catalog No. T7194   CAS 1846570-31-7

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CM-272 Chemical Structure
CM-272, CAS 1846570-31-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 67.00
5 mg In stock $ 163.00
10 mg In stock $ 289.00
25 mg In stock $ 538.00
50 mg In stock $ 777.00
100 mg In stock $ 1,090.00
1 mL * 10 mM (in DMSO) In stock $ 173.00
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Purity: 98.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Targets&IC50 DNMT1:382 nM, DNMT3a:85 nM, GLP:2 nM, G9a:8 nM, DNMT3B:1200 nM (IC50)
In vitro CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
In vivo CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
Cell Research Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours
Animal Research CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days
Molecular Weight 478.63
Formula C28H38N4O3
CAS No. 1846570-31-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 96 mg/mL (200.57 mM)

Ethanol: 96 mg/mL (200.57 mM)

TargetMolReferences and Literature

1. San José-Enériz, Edurne, Agirre X , Rabal O , et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies[J]. Nature Communications, 2017, 8:15424.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library NO PAINS Compound Library Epigenetics Compound Library Inhibitor Library Methylation Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Chromatin Modification Compound Library Reprogramming Compound Library Apoptosis Compound Library

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Keywords

CM-272 1846570-31-7 Apoptosis Chromatin/Epigenetic Histone Methyltransferase DNA Methyltransferase DNMT1 anti-tumour DNMTs immunogenic DNA MTases DNMT3A G9a H3K9me2 Inhibitor epigenetics GLP inhibit substrate-competitive DNMT3B CM272 CM 272 inhibitor

 

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