anti-proliferation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2054	Periplocymarin		Calcium Channel
	Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.		Calcium Channel
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor
T8839	ICCB280		Apoptosis , Others
	ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo...		Apoptosis , Others
T11284	FIDAS-3		Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT)
	FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ...
T11285	FIDAS-5		Others
	FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.		Others
T7138	FB23-2		Apoptosis , Others
	FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM).		Apoptosis , Others
T13996	1-Naphthohydroxamic acid		HDAC
	1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d...		HDAC
T1923	BRD4770		Histone Methyltransferase
	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.		Histone Methyltransferase
T9195	SHR0302	ARQ252	Apoptosis , JAK
	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).		Apoptosis , JAK
T8872	(Rac)-JBJ-04-125-02	JBJ-04-125-02	EGFR
	(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.		EGFR
T1995	Fedratinib	TG-101348,SAR 302503	Apoptosis , FLT , c-RET , JAK
	Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.		Apoptosis , FLT , c-RET , JAK
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
T2680	NVP-BVU972		c-Met/HGFR
	NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.		c-Met/HGFR
T5168	EGFR-IN-12	EGFR Inhibitor	Apoptosis , EGFR
	EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.		Apoptosis , EGFR
T3661	Citarinostat	ACY241,HDAC-IN-2	HDAC
	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...		HDAC
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
T9251	Fedratinib hydrochloride hydrate	TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate	Apoptosis , JAK
	Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.		Apoptosis , JAK
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T2028	NG 52	NG52,NG-52,Compound 52	CDK
	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.		CDK
T2275	YK-4-279		Apoptosis , DNA/RNA Synthesis
	YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.		Apoptosis , DNA/RNA Synthesis