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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39341 | FCPR03 | PDE | |
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr... | |||
T39195 | YM-244769 dihydrochloride | Calcium Channel | |
YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys. | |||
T9888 | YM-244769 | 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- | Calcium Channel |
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effec... | |||
T0080 | Trapidil | Rocornal,Trapymine,Avantrin,Trapymin,AR-12008 | PDGFR , PDE |
Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease. | |||
T77442 | Glenzocimab | ACT017 | Others |
Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ... | |||
T0988 | Trimetazidine dihydrochloride | Yoshimilon,Kyurinett,Vastarel F | Autophagy , Fatty Acid Synthase |
Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in isch... | |||
T2S1008 | Oxysophoridine | Sophoridine N-oxide | Apoptosis , Antioxidant |
Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ... | |||
TN1956 | Mulberrofuran G | Phosphatase , HBV , Glucosidase | |
Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the... | |||
T3752 | 4-Hydroxybenzyl alcohol | 4-Methylolphenol,P-Methylolphenol | Apoptosis , Endogenous Metabolite |
4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe... | |||
T3S1553 | Trans-Cinnamaldehyde | Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein | COX , Endogenous Metabolite |
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells... | |||
T3527 | TRC051384 | TRC 051384 | HSP |
TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ... | |||
TL0008 | Gigantol | Wnt/beta-catenin , Glucosidase | |
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a... | |||
T4S2326 | Cornuside | 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside | ERK , p38 MAPK , NF-κB , JNK |
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi... | |||
T26018 | R 59494 | R-59494,R59494 | |
R 59494 is a novel anti-ischemic molecule. | |||
T25575 | KF 14124 | KF14124,Dptpp-2-ismn,KF-14124 | |
KF 14124 exhibits potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats). | |||
T11080 | Dopropidil | Calcium Channel | |
Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models. | |||
TN5498 | 6,7,4'-Trihydroxyflavanone | Others | |
6,7,4'-Trihydroxyflavanone possesses various pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic, and protective effects against METH-induced deactivation of T ce... | |||
T81581 | OY-201 | ||
OY-201 is a promising anti-ischemic stroke agent capable of crossing the blood-brain barrier (BBB). It demonstrates significant safety and neuroprotective activity in in vitro and in vivo models [1]. | |||
T61540 | F15845 | ||
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio... | |||
T74191 | Tanshinol borneol ester | ||
Tanshinol borneol ester, an angiogenesis stimulator, enhances several critical phases of angiogenesis via the Akt and MAPK signaling pathways. This compound also exhibits anti-ischemic and anti-atherosclerosis properties... |