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TRC051384

Catalog No. T3527   CAS 867164-40-7
Synonyms: TRC 051384

TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.

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TRC051384 Chemical Structure
TRC051384, CAS 867164-40-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 45.00
2 mg In stock $ 64.00
5 mg In stock $ 101.00
10 mg In stock $ 182.00
25 mg In stock $ 377.00
50 mg In stock $ 552.00
100 mg In stock $ 787.00
200 mg In stock $ 1,070.00
1 mL * 10 mM (in DMSO) In stock $ 110.00
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Purity: 92.66%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.
In vitro TRC051384 induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons in a dose-dependently manner. Treatment with TRC051384 results in a significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line[1].
In vivo Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even though administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity[1].
Cell Research HeLa cell transiently co-transfected with heat shock elements-luciferase reporter and normalization vector, β-galactosidase are treated with vehicle or TRC051384 (12.5 and 25 μM) for 4 hours. Cell lysates are then prepared and analyzed for luciferase and β-galactosidase activity[1].
Synonyms TRC 051384
Molecular Weight 465.54
Formula C25H31N5O4
CAS No. 867164-40-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL

TargetMolReferences and Literature

1. Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.

Related compound libraries

This product is contained In the following compound libraries:
Endoplasmic Reticulum Stress Compound Library Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library Covalent Inhibitor Library Anti-Fibrosis Compound Library Target-Focused Phenotypic Screening Library Immunology/Inflammation Compound Library

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Keywords

TRC051384 867164-40-7 Cytoskeletal Signaling Metabolism HSP TRC-051384 TRC 051384 Heat shock proteins Inhibitor inhibit inhibitor

 

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