vastatin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T20765	Atorvastatin		HMG-CoA Reductase , Autophagy
	Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i...		HMG-CoA Reductase , Autophagy
T12490	Pitavastatin lactone		Others
	Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.		Others
T24865	Tenivastatin	L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid	ROS , HMG-CoA Reductase
	Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia.		ROS , HMG-CoA Reductase
T12652	(Rac)-5-Keto Fluvastatin	5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin	Others
	(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) is an impurity of Fluvastatin which is an inhibitor of HMG-CoA reductase.		Others
T1487	Fluvastatin sodium	XU 62320 sodium,XU-62-320,Fluvastatin sodium salt	Ferroptosis , HMG-CoA Reductase , Autophagy
	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.		Ferroptosis , HMG-CoA Reductase , Autophagy
T3116	Atorvastatin hemicalcium salt	Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis	Ferroptosis , HMG-CoA Reductase , Autophagy
	Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.		Ferroptosis , HMG-CoA Reductase , Autophagy
T21405	Fluvastatin	Canef,XU-62320,Vastin,Cranoc,Lescol	HMG-CoA Reductase
	Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction ...		HMG-CoA Reductase
T13131	Tert-Buthyl Pitavastatin		HMG-CoA Reductase
	tert-Buthyl Pitavastatin is Pitavastatin metabolite. Pitavastatin is a potent inhibitor of HMG-CoA reductase.		HMG-CoA Reductase
T14342	Atorvastatin lactone		HMG-CoA Reductase
	Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.		HMG-CoA Reductase
T25285	Dalvastatin	RG-12561,RG 12561,RG12561	HMG-CoA Reductase
	Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvast...		HMG-CoA Reductase
T2534	Pitavastatin calcium	P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104	Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
TQ0045	2-Hydroxy atorvastatin calcium salt		Drug Metabolite
	2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).		Drug Metabolite
T25276	Crilvastatin	PMD387,PMD 387,PMD-387	HMG-CoA Reductase
	Crilvastatin (PMD 387) is a novel non-competitive hydroxymethylglutaryl coenzyme A reductase inhibitor with cholesterol-lowering activity that inhibits cholesterol uptake in rats with hereditary hypercholesterolemia.		HMG-CoA Reductase
T20887	Atorvastatin Sodium	Lipitor	LDL , Aquaporin , HMG-CoA Reductase
	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...		LDL , Aquaporin , HMG-CoA Reductase
T10324	Anhydrosimvastatin	Dehydro simvastatin	HMG-CoA Reductase
	Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.		HMG-CoA Reductase
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T19918	Lovastatin hydroxy acid sodium	6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium
	Lovastatin Sodium is an HMG-CoA reductase inhibitor.
T39036	(3R,5S)-Fluvastatin	(3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid
	(3R,5S)-Fluvastatin, the 3R,5S-isomer of Fluvastatin (XU 62-320 free acid), stands as the inaugural fully synthetic, competitive inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It safeguards vascular sm...
T63430	Rosuvastatin Sodium
	Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor (IC50: 11 nM) that effectively blocks hERG currents (IC50: 195 nM). Rosuvastatin Sodium reduces the expression of mature hERG and inhibits the inte...
T69006	Atorvastatin lysine
	Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor.
T68566	Pitavastatin methyl ester
	Pitavastatin methyl ester is the methyl ester derivative of Pitavastatin -- a competitive inhibitor of HMG-CoA reductase and an anti-lipemic agent.
T10130	(3S,5R)-Pitavastatin calcium		Others
	(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.		Others
T13380	(Z)-Pitavastatin calcium		Others
	(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.		Others
T72101	Atorvastatin hemicalcium trihydrate
	Atorvastatin Hemicalcium Trihydrate, an orally active HMG-CoA reductase inhibitor, effectively reduces blood lipids. It also inhibits human SV-SMC proliferation and invasion, showing IC50 values of 0.39 μM and 2.39 μM, r...
T10235	Acetyllovastatin		Others
	Acetyllovastatin (acetate of Lovastatin) presents a moderate inhibitory effect against the acetylcholinesterase (IC50: 79 μg/mL). Lovastatin displays antifungal activity and suppresses the proliferation of a number of tr...		Others
T10401	Atorvastatin acetonide		Others
	Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.		Others
T72155	(Rac)-3′-Hydroxy simvastatin
	(Rac)-3′-Hydroxy Simvastatin, a metabolite of Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, demonstrating a K i value of 0.2 nM.
T10136	4-Acetylsimvastatin		Others
	4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).		Others
T38249	2-Hydroxy atorvastatin lactone
	2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].
T11306	Fluvastatin D6 sodium	XU 62-320 (D6)	Others
	Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin D6 sodium is deuterium labeled Fluvastatin sodium.		Others
T19551	Rosuvastatin D6 Calcium		Others
	Rosuvastatin D6 Calcium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).		Others
T12757	Rosuvastatin D3 Sodium		Others
	Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).		Others
T10132	(3S,5S)-Pitavastatin calcium		Others
	(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.		Others
T10129	(3S,5R)-Fluvastatin sodium	(3S,5R)-XU 62-320	Others
	(3S,5R)-Fluvastatin sodium is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor (IC50: 8 nM). Fluvastatin protects vascular smooth muscle cells against...		Others
T37642	Pravastatin lactone
	Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin ...
T64292	Simvastatin acid calcium hydrate
	Simvastatin acid (Tenivastatin) calcium hydrate is an orally active inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid calcium hydrate also inhibits indoxyl sulfate mediated reactive oxygen species (ROS) production...
T21080	(3S,5S)-Atorvastatin	ent-Atorvastatin,3S,5S-Atorvastatin
	ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).
T35718	N-desmethyl Rosuvastatin (sodium salt hydrate)
	N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) is...
T10070	2'-Ethyl Simvastatin		HMG-CoA Reductase
	2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.		HMG-CoA Reductase
T10120	3-Oxo Atorvastatin		Others
	3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.		Others
T40557	Simvastatin Acyl-β-D-glucuronide
	Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.
T10131	(3S,5R)-Rosuvastatin		Others
	(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).		Others
T15127	Difluoro atorvastatin	Fluoroatorvastatin	Others
	Difluoro atorvastatin is an Atorvastatin impurity. Atorvastatin is an orally active HMG-CoA reductase inhibitor and it has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferatio...		Others
T30202	Atorvastatin, (3S,5R)-	AT10 Trans
	Atorvastatin, (3S,5R)- is an Atorvastatin impurity.
T82900	Bemfivastatin hemicalcium	PPD 10558 hemicalcium
	Bemfivastatin hemicalcium (PPD 10558), an orally active HMG-CoA reductase inhibitor, serves as a lipid-lowering agent. It amplifies liver extract activity and exhibits no-observed adverse effect levels (NOAEL) at dosages...
TMIH-0052	3S,5R-Fluvastatin-d6
	3S,5R-Fluvastatin-d6 is a deuterated compound of 3S,5R-Fluvastatin. 3S,5R-Fluvastatin has a CAS number of 94061-81-1.
T12488	Pitavastatin D4	NK-104 D4	Others
	Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase.		Others
T62598	Pitavastatin sodium
	Pitavastatin (NK-104) sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and a potent inducer of the hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor. pitavastatin sodium inhibit...
T10127	(3R,5S)-Atorvastatin sodium		Others
	(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.		Others

Compounds

Atorvastatin

T20765

Synonym:

Target: HMG-CoA Reductase, Autophagy

Synonym: L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid

Target: ROS, HMG-CoA Reductase

(Rac)-5-Keto Fluvastatin

T12652

Synonym: 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin

Target: Others

Fluvastatin sodium

T1487

Synonym: XU 62320 sodium,XU-62-320,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Atorvastatin hemicalcium salt

T3116

Synonym: Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Fluvastatin

T21405

Synonym: Canef,XU-62320,Vastin,Cranoc,Lescol

Target: HMG-CoA Reductase

Tert-Buthyl Pitavastatin

T13131

Synonym:

Target: HMG-CoA Reductase

Atorvastatin lactone

T14342

Synonym:

Target: HMG-CoA Reductase

Dalvastatin

T25285

Synonym: RG-12561,RG 12561,RG12561

Target: HMG-CoA Reductase

Pitavastatin calcium

T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Rosuvastatin calcium

T1510

Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

2-Hydroxy atorvastatin calcium salt

TQ0045

Synonym:

Target: Drug Metabolite

Crilvastatin

T25276

Synonym: PMD387,PMD 387,PMD-387

Target: HMG-CoA Reductase

Atorvastatin Sodium

T20887

Synonym: Lipitor

Target: LDL, Aquaporin, HMG-CoA Reductase

Anhydrosimvastatin

T10324

Synonym: Dehydro simvastatin

Target: HMG-CoA Reductase

Rosuvastatin

T1676

Synonym: ZD 4522

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Lovastatin hydroxy acid sodium

T19918

Synonym: 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium

Target:

(3R,5S)-Fluvastatin

T39036

Synonym: (3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid

Pitavastatin methyl ester

T68566

Synonym:

Target:

(3S,5R)-Pitavastatin calcium

T10130

Synonym:

Target: Others

(Z)-Pitavastatin calcium

T13380

Synonym:

Target: Others

Atorvastatin hemicalcium trihydrate

Atorvastatin acetonide

T10401

Synonym:

Target: Others

(Rac)-3′-Hydroxy simvastatin

2-Hydroxy atorvastatin lactone

T38249

Synonym:

Target:

Fluvastatin D6 sodium

T11306

Synonym: XU 62-320 (D6)

Target: Others

Rosuvastatin D6 Calcium

T19551

Synonym:

Target: Others

Rosuvastatin D3 Sodium

T12757

Synonym:

Target: Others

(3S,5S)-Pitavastatin calcium

T10132

Synonym:

Target: Others

(3S,5R)-Fluvastatin sodium

T10129

Synonym: (3S,5R)-XU 62-320

Simvastatin acid calcium hydrate

Synonym: ent-Atorvastatin,3S,5S-Atorvastatin

Target:

N-desmethyl Rosuvastatin (sodium salt hydrate)

Target: HMG-CoA Reductase

Simvastatin Acyl-β-D-glucuronide

Difluoro atorvastatin

T15127

Synonym: Fluoroatorvastatin

Target: Others

Atorvastatin, (3S,5R)-

T30202

Synonym: AT10 Trans

Target:

Bemfivastatin hemicalcium

T82900

Synonym: PPD 10558 hemicalcium

(3R,5S)-Atorvastatin sodium

T10127

Synonym:

Target: Others

Cat No.	Product Name	Synonyms	Targets
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T1207	Lovastatin	MK-803,Mevinolin	Ferroptosis , HMG-CoA Reductase , Autophagy
	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.		Ferroptosis , HMG-CoA Reductase , Autophagy
T0672	Pravastatin sodium	CS-514 Sodium,CS-514 (sodium)	Ferroptosis , HMG-CoA Reductase , Autophagy
	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.		Ferroptosis , HMG-CoA Reductase , Autophagy
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T16885	Simvastatin acid ammonium	Tenivastatin ammonium	Others
	Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 ce...		Others

Cat No.	Product Name	Species	Expression System
TMPJ-00921	COL8A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endo...

Search Result

Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins