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Pitavastatin calcium

Catalog No. T2534 CAS 147526-32-7

Synonyms: P-872441, nisvastatin, itavastatin, Pitavastatin hemicalcium, NK-104

Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.

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Pitavastatin calcium, CAS 147526-32-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 54.00
25 mg	In stock	$ 76.00
50 mg	In stock	$ 98.00
100 mg	In stock	$ 171.00
200 mg	In stock	$ 239.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 100%

Purity: 99.71%

Purity: 98.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Targets&IC50	HMG-CoA:5.8 nM
In vivo	Pitavastatin inhibits the progression of arterial atherosclerosis by blocking the synthesis of thromboxane and suppressing the migration or proliferation of vascular smooth muscle induced by angiotensin II, thereby stabilizing atherosclerotic plaques. It significantly reduces the levels of intracellular and synthesized cholesteryl esters. Moreover, pitavastatin enhances the extracellular expression of LDL receptors and increases the binding of LDL to LDL receptors. Compared to simvastatin and atorvastatin, pitavastatin is more effective in inducing the expression of LDL receptor mRNA.

Synonyms	P-872441, nisvastatin, itavastatin, Pitavastatin hemicalcium, NK-104
Molecular Weight	880.98
Formula	C50H46CaF2N2O8
CAS No.	147526-32-7

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44.1 mg/mL (100 mM)

References and Literature

1. Ahmad H, et al. Cardiol Rev, 2010, 18(5):264-267. 2. Martin G, et al. J Clin Invest, 2001, 107(11), 1423-1432. 3. Ohnaka K, et al. Biochem Biophys Res Commun, 2001, 287(2), 337-342. 4. Olsson AG, et al. Cardiovasc Drug Rev. 2002, 20(4):303-28.

Citations

1. Zhang W, Pan X, Xu Y, et al.Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.Acta Pharmaceutica Sinica B.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Metabolism Compound Library Lipid Metabolism Compound Library Anti-Viral Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pitavastatin calcium 147526-32-7 Apoptosis Autophagy Metabolism Mitophagy HMG-CoA Reductase Endogenous Metabolite P-872441 NK104 HMG-CoA Reductase (HMGCR) P 872441 inhibit nisvastatin Pitavastatin P872441 itavastatin Inhibitor Pitavastatin hemicalcium NK 104 NK-104 hemicalcium NK-104 Mitochondrial Autophagy inhibitor

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