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Pitavastatin calcium

Catalog No. T2534   CAS 147526-32-7
Synonyms: Pitavastatin hemicalcium, NK-104, 匹伐他汀钙, itavastatin, nisvastatin, P-872441

Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.

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Pitavastatin calcium, CAS 147526-32-7
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Targets&IC50 HMG-CoA:5.8 nM
Synonyms Pitavastatin hemicalcium, NK-104, 匹伐他汀钙, itavastatin, nisvastatin, P-872441
Molecular Weight 880.999
Formula C50H46CaF2N2O8
CAS No. 147526-32-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 44.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ahmad H, et al. Cardiol Rev, 2010, 18(5):264-267. 2. Martin G, et al. J Clin Invest, 2001, 107(11), 1423-1432. 3. Ohnaka K, et al. Biochem Biophys Res Commun, 2001, 287(2), 337-342. 4. Olsson AG, et al. Cardiovasc Drug Rev. 2002, 20(4):303-28.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Glutamine Metabolism Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Anti-Metabolism Disease Compound Library Anti-Alzheimer's Disease Compound Library Fluorochemical Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pitavastatin calcium 147526-32-7 代谢 凋亡 自噬 Apoptosis Autophagy Endogenous Metabolite HMG-CoA Reductase Mitophagy Pitavastatin hemicalcium HMG-CoA Reductase (HMGCR) inhibit Inhibitor itavastatin nisvastatin NK-104 hemicalcium NK-104 Mitochondrial Autophagy P-872441 Pitavastatin inhibitor