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Pitavastatin calcium

Catalog No. T2534 CAS 147526-32-7

Synonyms: Pitavastatin hemicalcium, NK-104, 匹伐他汀钙, itavastatin, nisvastatin, P-872441

Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.

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Pitavastatin calcium, CAS 147526-32-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Targets&IC50	HMG-CoA:5.8 nM

Synonyms	Pitavastatin hemicalcium, NK-104, 匹伐他汀钙, itavastatin, nisvastatin, P-872441
Molecular Weight	880.999
Formula	C50H46CaF2N2O8
CAS No.	147526-32-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 44.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ahmad H, et al. Cardiol Rev, 2010, 18(5):264-267. 2. Martin G, et al. J Clin Invest, 2001, 107(11), 1423-1432. 3. Ohnaka K, et al. Biochem Biophys Res Commun, 2001, 287(2), 337-342. 4. Olsson AG, et al. Cardiovasc Drug Rev. 2002, 20(4):303-28.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Glutamine Metabolism Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Anti-Metabolism Disease Compound Library Anti-Alzheimer's Disease Compound Library Fluorochemical Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pitavastatin calcium 147526-32-7 代谢凋亡自噬 Apoptosis Autophagy Endogenous Metabolite HMG-CoA Reductase Mitophagy Pitavastatin hemicalcium HMG-CoA Reductase (HMGCR) inhibit Inhibitor itavastatin nisvastatin NK-104 hemicalcium NK-104 Mitochondrial Autophagy P-872441 Pitavastatin inhibitor

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