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Simvastatin acid ammonium

Catalog No. T16885 CAS 139893-43-9

Synonyms: Tenivastatin ammonium

Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

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Simvastatin acid ammonium Chemical Structure

Simvastatin acid ammonium, CAS 139893-43-9

Pack Size	Availability	Price/USD
5 mg	5 days	$ 39.00
10 mg	5 days	$ 73.00
1 mL * 10 mM (in DMSO)	5 days	$ 45.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
In vitro	The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells. There is a pH-dependent effect on organic anion transporting polypeptide 3A1 uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene [1].

Synonyms	Tenivastatin ammonium
Molecular Weight	453.62
Formula	C25H43NO6
CAS No.	139893-43-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.

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Keywords

Simvastatin acid ammonium 139893-43-9 Others Tenivastatin ammonium inhibitor inhibit

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