Home Tools

Cart

Pravastatin sodium

Catalog No. T0672 CAS 81131-70-6

Synonyms: CS-514 Sodium, CS-514 (sodium)

Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pravastatin sodium, CAS 81131-70-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 40.00
25 mg	In stock	$ 55.00
50 mg	In stock	$ 66.00
100 mg	In stock	$ 101.00
200 mg	In stock	$ 130.00
500 mg	In stock	$ 215.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

Bulk Inquiry

Select Batch

Purity: 99.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
Targets&IC50	HMG-CoA reductase:5.6 μM
In vitro	Pravastatin (30 mg/kg/day) reduced malnutrition-induced lesions by 34%. In female Wistar rats exposed to radiation, which presented with decreased CCN2 levels, Pravastatin (30 mg/kg/day) could restore muscle structure. A single dose of 40 mg of Pravastatin lowered cholesterol synthesis by 62% in monocytes from healthy individuals and by 47% in patients with hypercholesterolemia. Moreover, treatment with Pravastatin (40 mg/day for 8 weeks) in hypercholesterolemic patients increased LDL degradation by 57% while inhibiting cholesterol synthesis by 55%.
In vivo	In murine peritoneal macrophages (MPM), the J-774 A.1 macrophage-like cell line, and human monocyte-derived macrophages (HMDM), Pravastatin exhibits a dose-dependent inhibition of cholesterol synthesis. Upon LDL addition, concentrations of Pravastatin below 0.19 μg/mL enhance the esterification of cellular cholesterol, whereas levels below 100 μg/mL suppress esterification. At less than 0.5 mM, Pravastatin attenuates the Rho/ROCK pathway activity in human ileal and colonic transplants, reducing CCN2 mRNA levels. Pravastatin at concentrations less than 1 mM also induces the inhibition of CCN2 in primary human smooth muscle cells. In all cases, Pravastatin at less than 0.5 mM reduces the mRNA levels of type I collagen and fibronectin. Pravastatin facilitates vasodilation in aortic rings, achieving 62.8% endothelium-dependent relaxation at 10 μM after 8 minutes. Pravastatin-Na at 10 μM inhibits sterol synthesis with 50% greater efficacy than in peripheral blood mononuclear cells. In bovine aortic endothelial cells, Pravastatin at less than 10 μM stimulates NOS activity and NO release within 10 minutes, with L-arginine further enhancing NO production in response to Pravastatin.

Synonyms	CS-514 Sodium, CS-514 (sodium)
Molecular Weight	446.52
Formula	C23H35NaO7
CAS No.	81131-70-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 44.7 mg/mL (100 mM)

DMSO: 44.7 mg/mL (100 mM)

References and Literature

1. Kurakata S, et al. Immunopharmacology, 1996, 34(1), 51-61. 2. Kaesemeyer WH, et al. J Am Coll Cardiol, 1999, 33(1), 234-241. 3. Keidar S, et al. Br J Clin Pharmacol, 1994, 38(6), 513-519. 4. Haydont V, et al. Clin Cancer Res, 2007, 13(18 Pt 1), 5331-5340. 5. Dagli N, et al. Inflammation, 2007, 30(6), 230-235. 6. Huang Y, Zucker B, Zhang S, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains[J]. Nature cell biology. 2019, 21(8): 991.

Citations

1. Huang Y, Zucker B, Zhang S, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nature cell biology. 2019, 21(8): 991.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Microbial Natural Product Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Metabolism Compound Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Lipid Compound Library Orally Active Compound Library

Related Products

Related compounds with same targets

Setanaxib Deferoxamine Mesylate Nordihydroguaiaretic acid Pioglitazone Pifithrin-β hydrobromide PRIMA-1 Lovastatin Alogliptin

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pravastatin sodium 81131-70-6 Apoptosis Autophagy Metabolism Ferroptosis HMG-CoA Reductase Pravastatin CS514 HMG-CoA Reductase (HMGCR) inhibit Inhibitor CS 514 CS-514 Sodium CS-514 (sodium) CS-514 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.