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Fluvastatin

Catalog No. T21405 CAS 93957-54-1

Synonyms: Canef, XU-62320, Vastin, Cranoc, Lescol

Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction of plasma cholesterol levels and the prevention of cardiovascular disease.

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Fluvastatin, CAS 93957-54-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 44.00
50 mg	In stock	$ 61.00
100 mg	In stock	$ 87.00

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Purity: 98.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction of plasma cholesterol levels and the prevention of cardiovascular disease.
Targets&IC50	HMG-CoA reductase:8 nM

Synonyms	Canef, XU-62320, Vastin, Cranoc, Lescol
Molecular Weight	411.47
Formula	C24H26FNO4
CAS No.	93957-54-1

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 2 mg/mL (4.87 mM), Sonication is recommended.

References and Literature

1. Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84. 2. Wu Zhang, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74. 3. Neuvonen PJ, Backman JT, Niemi M. Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Clin Pharmacokinet. 2008;47(7):463-74. Review. PubMed PMID: 18563955. 4. Stein EA, Corsini A, Gimpelewicz CR, Bortolini M, Gil M. Fluvastatin treatment is not associated with an increased incidence of cancer. Int J Clin Pract. 2006 Sep;60(9):1028-34. Review. PubMed PMID: 16939542.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fluvastatin 93957-54-1 Metabolism HMG-CoA Reductase Canef XU-62320 XU 62320 Vastin XU62320 Cranoc Lescol inhibitor inhibit

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