paf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14007	PAF-AN-1		PAFR
	PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.		PAFR
T21547	PAF (C16)	C16-PAF	ERK , MEK , MAPK , Endogenous Metabolite
	PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled...		ERK , MEK , MAPK , Endogenous Metabolite
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and pur...
T36764	PAF C-18:1
	PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the ...
T36763	PAF C-18
	PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggrega...
T36205	Methylcarbamyl PAF C-16
	Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its abilit...
T37268	PAF C-16 Carboxylic Acid
	PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production o...
T19104	2-Thio-PAF		Others
	2-Thio-PAF is a synthetic analog of PAF used in a colorimetric assay for PAF acetylhydrolase.		Others
T29308	Lyso-PAF C-16
	Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor.
T6242	Rupatadine Fumarate	Rinialer,Rupafin,Alergoliber	PAFR , Autophagy , Histamine Receptor
	Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.		PAFR , Autophagy , Histamine Receptor
TN4222	Homoeriodictyol 7-O-β-D-glucoside	Homoeriodictyol 7-O-glucoside	Others , Platelet aggregation
	Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) is a natural product from Viscum coloratum(Kom.)Nakai. Homoeriodictyol 7-O-β-D-glucoside is an antagonist of platelet-activating factor (PAF).		Others , Platelet aggregation
T15338	Foropafant	SR27417	Others , Platelet aggregation
	Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.		Others , Platelet aggregation
T28607	Rocepafant	LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation
	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor...		Platelet aggregation
T17178	Tulopafant	RP 59227	PAFR
	Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.		PAFR
T9445	Vepafestinib		c-RET
	Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].		c-RET
T68124	Pafenolol		Adrenergic Receptor , P-gp
	Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.		Adrenergic Receptor , P-gp
T1280	Nepafenac	AL 6515,AHR 9434	COX
	Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds.		COX
T0866	Propafenone	Rythmol,Propafenonum	Potassium Channel , MRP , Sodium Channel
	Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....		Potassium Channel , MRP , Sodium Channel
T6955	Propafenone hydrochloride	Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,Rythmol	Sodium Channel
	Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.		Sodium Channel
T14300	Apafant	WEB 2086	Others
	Apafant is a potent antagonist of platelet-activating factor (PAF), inhibits PAF binding to human PAF receptors(Ki : 9.9 nM).		Others