Search Result

Search Results for " npc "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T21060L	NPC 567 acetate	NPC 567 acetate(109333-26-8 Free base)	Bradykinin Receptor
	NPC 567 acetate is a bradykinin B2 antagonist and can be used in studies about the treatment of allergic airway disease.		Bradykinin Receptor
T8638	NPC 15199	FMOC-L-Leucine	Others
	NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.		Others
T33729	Npc 573	Npc-573,Npc573
	Npc 573 is a bioactive chemical.
T70187	NPC-18915
	NPC-18915 is a benzofuran compound, inhibitor of neutophil activation.
T77407	Ensituximab	NPC-1C,NEO-102,NEO-101
	Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer.
T37480	NPC-15437 (hydrochloride)
	NPC-15437 (hydrochloride) is a scleclive inhibitor of PKC interacling at the regulatory domain of the enzyme。
T71024	NPC-16731
	NPC-16731 is a Bradykinin antagonist.
T21060	NPC 567
	NPC 567 is an antagonist of the bradykinin receptor.
T71323	Npc 12626
	Npc 12626 is a N-methyl-D-aspartate receptor antagonist; NPC 17742, the (2R,4R,5S)-isomer, is the most potent isomer in the mixture NPC 12626.
T18105	M-PEG-NPC (MW 20000)		Others
	m-PEG-NPC (MW 20000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others
T70576	NPC 17731
	NPC 17731 is a bradykinin receptor antagonist.
T70574	NPC 17761
	NPC 17761 is a bradykinin receptor antagonist.
T70590	NPC-14695
	NPC-14695 is a smooth muscle-selective muscarinic antagonist with bronchodilating activity.
T19553	RPR132595A	NPC	Others
	RPR132595A is an active CPT-11 metabolite, it is generated by cytochrome P-450 3A4 (CYP3A4).		Others
T78069	RPR132595A hydrochloride	NPC hydrochloride	Drug Metabolite
	RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary excretion [1].		Drug Metabolite
T71321	(S)-VU0637120		Others
	(S)-VU0637120 is a selective neuropeptide Y(4)R-mutant antagonist used in the study of metabolic disorders.		Others
T70588	Tazemetostat HCl
	Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal flu...
T70572	CHF-2060
	CHF-2060 is a novel acetylcholinesterase inhibitor.
T71023	MI-888 free base
	MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenogra...
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
TP1847	GLGPNPCRKKCYKRDFLGR
	GLGPNPCRKKCYKRDFLGR is a synthetic peptide.
TP1781	Nuclear pore complex protein Nup98 315-360
	Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment part of the nuclear pore complex (NPC) protein.
T83667	A11 TFA	CPP-EYVQTVKSSKG
	A11, a cell-penetrating peptide, integrates the HIV-1 Tat protein transduction domain with an 11-amino acid segment from the annexin A1 N-terminus (residues 20-30). This compound disrupts the interaction between annexin ...
T77010	Fiztasovimab
	Fiztasovimab (NPC-21; EV2038), a fully human IgG1λ monoclonal antibody (mAb), targets human cytomegalovirus (hCMV). It exerts its neutralizing activity through binding to the antigenic domain 1 of glycoprotein B on the h...
T76970	Tagitanlimab
	Tagitanlimab (HBM-9167), a humanized anti-PD-L1 antibody (IgG1κ type), selectively inhibits the PD-L1 and PD-1 interaction. It shows promise for investigation in recurrent or metastatic nasopharyngeal carcinoma (NPC) [1]...
T81720	N,N'-Dinitrosopiperazine	1,4-Dinitrosopiperazine,DNP
	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen targeting nasopharyngeal epithelium that promotes nasopharyngeal carcinoma (NPC) metastasis. It modulates various signaling pathways via protein pho...

Compounds

NPC 567 acetate

T21060L

Synonym: NPC 567 acetate(109333-26-8 Free base)

Target: Bradykinin Receptor

NPC 15199

T8638

Synonym: FMOC-L-Leucine

Target: Others

Npc 573

T33729

Synonym: Npc-573,Npc573

Synonym: NPC-1C,NEO-102,NEO-101

Target:

NPC-15437 (hydrochloride)

m-PEG-NPC (MW 20000)

RPR132595A hydrochloride

T78069

Synonym: NPC hydrochloride

Target: Drug Metabolite

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Nuclear pore complex protein Nup98 315-360

Synonym: CPP-EYVQTVKSSKG

N,N'-Dinitrosopiperazine

T81720

Synonym: 1,4-Dinitrosopiperazine,DNP

Target:

Cat No.	Product Name	Synonyms	Targets
TN1854	Lasiodin	Lasiokaurin	P450 , PARP , Caspase
	Lasiodin (Lasiokaurin) is a diterpene compound from the plant Camellia sinensis that inhibits the proliferation of NPC cells. Lasiodin has antioxidant, antitumor and antibacterial activities, induces cell cycle length an...		P450 , PARP , Caspase
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
TN3922	Effusanin E		PARP , NF-κB , Caspase , COX , Antifection
	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .		PARP , NF-κB , Caspase , COX , Antifection
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 ...

Natural Products

Lasiodin

TN1854

Synonym: Lasiokaurin

Target: P450, PARP, Caspase

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Effusanin E

TN3922

Synonym:

Target: PARP, NF-κB, Caspase, COX, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00131	Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)	Human	HEK293 Cells
	Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pi...
TMPK-01298	BST2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune res...
TMPY-00264	NPC2 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	NPC2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.9 kDa and the accession number is Q8CHN5.
TMPY-01114	NPC2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NPC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P61916-1.
TMPY-04990	NPC2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	NPC2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.9 kDa and the accession number is Q9Z0J0.
TMPK-01203	TNFRSF19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for na...
TMPH-01524	KPNA1 Protein, Human, Recombinant (His)	Human	E. coli
	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate com...
TMPK-01204	TNFRSF19 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for na...
TMPY-02285	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein	H1N1	E. coli
	Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i...