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NPC 15199

Catalog No. T8638 CAS 35661-60-0

Synonyms: FMOC-L-Leucine

NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.

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NPC 15199, CAS 35661-60-0

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500 mg	In stock	$ 29.00

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Purity: 99.58%

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Description

NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.

In vitro

NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells.?Using fura-2 as a Ca2+ probe, NPC-15199 (0.1-2 mM) was found to increase [Ca2+]i concentration-dependently.?The response saturated at 2-5 mM NPC-15199.?The [Ca2+]i increase comprised an initial rise, a slow decay, and a plateau.?Ca2+ removal partly inhibited the Ca2+ signals.?In Ca2+-free medium, pretreatment with 1 mM NPC-15199 abolished the [Ca2+]i increase induced by 1 microM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor);?and after pretreatment with thapsigargin, NPC-15199-induced Ca2+ release was dramatically inhibited.?This indicates that NPC-15199 released internal Ca2+ mostly from the endoplasmic reticulum.?Adding 3 mM Ca2+ increased [Ca2+]i in cells pretreated with 1 mM NPC-15199 in Ca2+-free medium.?Together, the findings suggest that in BFTC bladder cancer cells, NPC-15199 induced Ca2+ release from the endoplasmic reticulum and activating Ca2+ entry.

Synonyms	FMOC-L-Leucine
Molecular Weight	353.41
Formula	C21H23NO4
CAS No.	35661-60-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (70.74 mM)

References and Literature

1. Jan C R , Yu C C , Huang J K . NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells[J]. Chinese Journal of Physiology, 2000, 43(1):29-33. 2. Effect of NPC-15199 on Ca2+ levels in renal tubular cells

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Anti-Fibrosis Compound Library Bioactive Compound Library ReFRAME Related Library NO PAINS Compound Library Anti-Aging Compound Library

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Keywords

NPC 15199 35661-60-0 Others NSC334290 FMOC-L-Leucine Fmoc-leucine NPC15199 inhibit Inhibitor NPC-15199 NSC 334290 Peroxisome proliferator-activated receptors PPAR NSC-334290 inhibitor

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