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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN7041 | (-)-Epipodophyllotoxin | Apoptosis | |
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit... | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T60026 | KIF18A-IN-2 | Microtubule Associated | |
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities. | |||
T21351 | Maytansine | NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine | Microtubule Associated , Antibiotic |
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T8492 | BO-264 | Apoptosis , FGFR | |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). | |||
T9521 | CHR-6494 TFA | Others | |
CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use... | |||
TQ0317 | R1530 | R-1530,R 1530 | VEGFR , FGFR , FLT , PDGFR |
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities. | |||
T8342 | BRD9876 | Others , Kinesin , Microtubule Associated | |
BRD9876 is a selective inhibitor of MM1S growth. | |||
T16156 | MT 63-78 | Apoptosis , AMPK , mTOR | |
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel... | |||
T19720 | Colcemid | C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine | Microtubule Associated |
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning. | |||
T6019 | Volasertib | BI 6727 | Apoptosis , PLK |
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). | |||
T9083 | TC11 | CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | BCL , Caspase , CDK |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. | |||
T2241 | Alisertib | MLN 8237 | Apoptosis , Aurora Kinase , Autophagy |
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B. | |||
T6393 | ARQ 621 | Kinesin | |
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. | |||
T3330L | Cis-trismethoxy Resveratrol | (Z)-3,5,4'-Trimethoxystilbene | Microtubule Associated |
cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects. | |||
T22455 | Vindesine sulfate | DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule... | |||
T4029 | BTB-1 | BTB 1,NSC156750 | Microtubule Associated |
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A. | |||
T20506 | Maleuric acid | N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778 | Others |
Maleuric acid (N-Carbamoylmaleamic acid) is anti-mitotic and can be used in biological research in conjunction with radioautography.Maleuric acid is used to improve the growth and fertility of plants and animals as well ... | |||
T4048 | Monastrol | (±)-Monastrol | Apoptosis , Kinesin |
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. |