Search Result

Search Results for " lrp "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T61132	NLRP3-IN-11		NOD
	NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.		NOD
T60442	NLRP3/AIM2-IN-3		NOD , AIM2
	NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of N...		NOD , AIM2
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T60404	NLRP3/AIM2-IN-2		AIM2
	NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.		AIM2
T61392	NLRP3-IN-10	ZVN26391	NOD
	NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.		NOD
T60756	NLRP3 antagonist 1
	NLRP3 antagonist 1 shows potential for the cancer research that is a potent NLRP3 antagonist. NLRP3 is involved in the body's intrinsic immunity against stress injury and pathogenic infections that is mainly expressed in...
T62809	NLRP3-IN-7
	NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.
T81666	NLRP3-IN-22		NOD-like Receptor (NLR)
	NLRP3-IN-22 (Compound II-4) is an inhibitor of NLRP3, exhibiting a 67% inhibition rate at a concentration of 10 μM [1].		NOD-like Receptor (NLR)
T62221	NLRP3-IN-8
	NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 1...
T73015	NLRP3-IN-16		NOD-like Receptor (NLR)
	NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].		NOD-like Receptor (NLR)
T61826	NLRP3-IN-4
	NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis.
T79733	NLRP3-IN-20		NOD-like Receptor (NLR)
	NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic propertie...		NOD-like Receptor (NLR)
T79695	NLRP3-IN-19	NLRP3-IN-19	NOD-like Receptor (NLR)
	JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the suppression of cytokine release and prevention of pyroptosis. J...		NOD-like Receptor (NLR)
T78180	NLRP3-IN-18		NOD-like Receptor (NLR)
	NLRP3-IN-18, also known as compound 13, is a potent inhibitor of NLRP3, demonstrating an IC50 value of ≤1.0 µM [1].		NOD-like Receptor (NLR)
T39607	NLRP3 modulators 1	NLRP3 modulators 1
	NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or...
T81668	NLRP3 agonist 1		NOD-like Receptor (NLR)
	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms [1].		NOD-like Receptor (NLR)
T73013	NLRP3-IN-14
	NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research...
T73018	NLRP3-IN-13
	NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATP...
T81665	NLRP3-IN-23		NOD-like Receptor (NLR)
	NLRP3-IN-23 (Compound 15C) is an inhibitor that significantly impedes heme-mediated activation of the NLRP3 inflammasome at a concentration of 0.1 μM [1].		NOD-like Receptor (NLR)
T81667	NLRP3 agonist 2		NOD-like Receptor (NLR)
	NLRP3 agonist 2 (compound 22) is an orally active agent that activates Caspase-1 in THP1 cells [1].		NOD-like Receptor (NLR)
T60563	NLRP3/AIM2-IN-1
	NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).
T62808	NLRP3-IN-6
	NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.
T78168	NLRP3-IN-17		NOD-like Receptor (NLR)
	NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent IL-1β secretion in mice, making it a valuable compound for...		NOD-like Receptor (NLR)
T78894	NLRP3-IN-21		NOD-like Receptor (NLR)
	NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ...		NOD-like Receptor (NLR)
T73014	NLRP3-IN-15
	NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of...
T73034	NLRP3-IN-12
	NLRP3-IN-12 is a specific inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release by targeting the NLRP3 protein, and demonstrating an IC50 of 0.45 μM. This compound is utilized in the research of inflamm...
T39552	NLRP3-IN-5	NLRP3-IN-5
	NLRP3-IN-5, a compound disclosed in WO2016131098, is an inhibitor of NLRP3 inflammasome. It consists of the chemical structure N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide.

Compounds

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

NLRP3-IN-9

T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3-IN-19

T79695

Synonym: NLRP3-IN-19

Target: NOD-like Receptor (NLR)

NLRP3-IN-18

T78180

Synonym:

Target: NOD-like Receptor (NLR)

NLRP3 modulators 1

T39607

Synonym: NLRP3 modulators 1

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3 agonist 2

T81667

Synonym:

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3-IN-21

T78894

Synonym:

Target: NOD-like Receptor (NLR)

Cat No.	Product Name	Synonyms	Targets
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
T5214	Cholesteryl linoleate	CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester	Others , Endogenous Metabolite
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...		Others , Endogenous Metabolite
TQ0215	Salinomycin sodium salt	Sodium salinomycin,Salinomycin sodium	Apoptosis , Wnt/beta-catenin , Antibacterial , Antibiotic , Autophagy
	Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.

Natural Products

Cholesteryl linoleate

T5214

Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester

Target: Others, Endogenous Metabolite

Salinomycin sodium salt

TQ0215

Synonym: Sodium salinomycin,Salinomycin sodium

Target: Apoptosis, Wnt/beta-catenin, Antibacterial, Antibiotic, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00744	LRP-6 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ...
TMPK-01063	LRP-10 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LDL receptor-related protein (LRP) 10 was recently identified as a Parkinson's disease gene through genome-wide linkage and sequencing analysis, but its role in Parkinson's disease in various populations is still unclear...
TMPK-00740	LRP-5 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that ...
TMPK-00739	LRP-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that ...
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c...
TMPY-06639	LRP-5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.21 kDa and the accession number is O75197-1.
TMPY-02748	LRP-10 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.5kDa and the accession number is Q7Z4F1-1.
TMPY-02653	LRP-10 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LRP-10 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73 kDa and the accession number is Q7Z4F1-1.
TMPY-03975	LRP-11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is Q86VZ4-1.
TMPY-06834	LRP-6 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LRP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.69 kDa and the accession number is O75581.
TMPY-06698	LRP-6 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.41 kDa and the accession number is O75581-1.
TMPY-02511	PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)	Human	Baculovirus Insect Cells
	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTP...
TMPY-00353	LRRC3B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LRRC3B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.7 kDa and the accession number is A1LNH5.
TMPY-00088	LRRC3B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRRC3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is A1LNH5.
TMPY-02883	C1D Protein, Human, Recombinant (GST)	Human	E. coli
	C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid h...
TMPH-01616	LRP2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	LRP2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50.8 kDa and the accession number is P98164.
TMPY-01732	LRPAP1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LRPAP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.4 kDa and the accession number is P55302.
TMPY-03182	PLRP2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Galactolipase, also known as PNLIPRP2, is a lipase with broad substrate specificity. It can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactoli...
TMPH-02502	LRPAP1 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. LRPAP1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells w...
TMPH-02796	NLRP3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	NLRP3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.2 kDa and the accession number is Q8R4B8.
TMPY-01233	LRPAP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRPAP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is P30533.
TMPH-01739	NLRP3 Protein, Human, Recombinant (His)	Human	E. coli
	NLRP3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is Q96P20.
TMPH-01738	NLRP1 Protein, Human, Recombinant (GST)	Human	E. coli
	NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000.
TMPY-01085	VLDLR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A...
TMPJ-00354	FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a sign...
TMPY-04422	Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran...
TMPK-01155	MANSC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MANSC1 contains 1 MANSC domain. MANSC is a seven-cysteine-containing domain present in animal membrane and extracellular proteins. MANSC (motif at N terminus with seven cysteines) is a novel domain with a well-conserved ...
TMPY-01451	MESDC2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a m...