ldl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10063	LDL-IN-3		Antioxidant
	LDL-IN-3 shows anti-atherosclerotic and antioxidant activities.		Antioxidant
T4039	BIBB 515		Others
	BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...		Others
T7832	Ibrolipim	NO-1886	LPL Receptor
	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.		LPL Receptor
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
T2626	SBC-115076	SBC115076	Others , Serine/threonin kinase
	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.		Others , Serine/threonin kinase
T9276	SBC-115337		Others , Serine/threonin kinase
	SBC-115337 is a PCSK9 inhibitor.		Others , Serine/threonin kinase
TN1438	Beta-Amyrin acetate		Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP
T4179	Probucol disuccinate		LDL
	Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.		LDL
T4058	R-IMPP		Others , Serine/threonin kinase
	R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.		Others , Serine/threonin kinase
TP1881L1	Pep 2-8 ammonium salt(1541011-97-5 free base)		Others
	Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.		Others
T5214	Cholesteryl linoleate	CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester	Others , Endogenous Metabolite
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...		Others , Endogenous Metabolite
T3625	Bempedoic acid	ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase , AMPK
	Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...		ATP Citrate Lyase , AMPK
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T0254	Probucol	DH-581	Virus Protease , ABC , Lipid
	Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.		Virus Protease , ABC , Lipid
T9916	Alirocumab		Others
	Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.		Others
T6S1930	Schisanhenol	Schizanhenol,Gomisin-K3	Antioxidant
	1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanheno...		Antioxidant
TN1511	Cleomiscosin A		LDL , Antioxidant , TNF
	Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin A can be used in studies about the prevention of LDL oxidat...		LDL , Antioxidant , TNF