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beta-Amyrin acetate

Catalog No. TN1438   CAS 1616-93-9

beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.

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beta-Amyrin acetate Chemical Structure
beta-Amyrin acetate, CAS 1616-93-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 145.00
10 mg In stock $ 193.00
25 mg In stock $ 347.00
50 mg In stock $ 515.00
100 mg In stock $ 747.00
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Purity: 99.74%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
In vitro beta-Amyrin acetate (25 μM) decreases mEH activity to 61% of control activity[1]. beta-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes[2]. beta-Amyrin acetate (7.8-1000 μg/mL) inhibits all of the Candida fungal species tested (MIC: 30 - 250 μg/mL)[5].
In vivo In Xylene-induced mouse ear topical edema model, beta-Amyrin acetate (100 μg/ear) significantly inhibits xylene-induced ear edema[2]. In normal and arthritic rats, beta-Amyrin acetate (40 mg/kg; s.c.) increases the ATP-phosphohydrolase activity in liver homogenates. In adult albino rats, beta-Amyrin acetate (40 mg/kg; i.p.) shows significant anti-inflammatory activities to 43.6% with mean average weight of granulation tissue of 9.2 mg after 6 days[4].
Source
Molecular Weight 468.75
Formula C32H52O2
CAS No. 1616-93-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

TargetMolReferences and Literature

1. Lee GH, et al. Discovery of soluble epoxide hydrolase inhibitors from natural products. Food Chem Toxicol. 2014 Feb;64:225-30. 2. Nkeoma Nkasi Okoye, et al. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharm Biol. 2014 Nov;52(11):1478-86. 3. Ranjani Maurya, et al. β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves. Phytomedicine. 2012 Jun 15;19(8-9):682-5. 4. M.B.Gupta, et al. Biochemical study of the anti-inflammatory activity of α and β-amyrin acetate. Biochemical Pharmacology. 1971 Feb; 2(20): 401-405. 5. S Johann, et al. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. Lett Appl Microbiol. 2007 Aug;45(2):148-53.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Bioactive Compound Library PBCRBS Traditional Chinese Medicine Compound Library Metabolism Compound Library Inhibitor Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Metabolite Library Anti-Cancer Metabolism Compound Library Natural Product Library Food as Medicine Compound Library

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Keywords

beta-Amyrin acetate 1616-93-9 Metabolism Microbiology/Virology oxidation-reduction HMG-CoA Reductase Antifungal Epoxide Hydrolase Antioxidant HMG-CoA betaAmyrin acetate LDL Fungal beta-Amyrin Acetate inhibit Inhibitor arthritic hemolysis antifungal b-Amyrin Acetate anti-inflammatory HMG-CoA Reductase (HMGCR) inflammation β-Amyrin beta Amyrin acetate β-Amyrin Acetate inhibitor

 

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