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Cat No. | Product Name | Synonyms | Targets |
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T15389L | Glucagon (1-29), bovine, human, porcine hydrochloride | Porcine glucagon hydrochloride,Glucagon hydrochloride | Glucocorticoid Receptor , Glucagon Receptor |
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon (1-29), bovine, human, porcine hydrochloride(Po... | |||
TP1863L | Glucagon (19-29), human acetate | Glucagon Receptor | |
Glucagon (19-29), human acetate a COOH-terminal fragment processed from glucagon, is a potent and efficient inhibitor of insulin secretion. | |||
TQ0239 | PF-06291874 | Glucagon receptor antagonists-4 | Glucagon Receptor |
PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor. | |||
T15389 | Glucagon (1-29), bovine, human, porcine | Porcine glucagon,Glucagon | Others |
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. | |||
T36638 | [Des-His1,Glu9]-Glucagon amide TFA | [Des-His1,Glu9]-Glucagon amide TFA | |
[Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist targeting the glucagon receptor, featuring a pA2 value of 7.2. It holds potential utility in diabetes pathogenesis research[1]. | |||
TP2033 | [Des-His1,Glu9]-Glucagon amide | des-His1-[Glu9]-Glucagon (1-29) amide | |
Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr... | |||
T37223 | Glucagon Receptor Antagonist I | ||
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor anta... | |||
T78059 | Glucagon (Human) | Hyperglycemic-glycogenolytic factor,Glukagon | Others |
Glucagon significantly impacts protein and amino acid metabolism. It hinders the integration of amino acids into the proteins of the liver, muscle, and pancreas, augmenting nitrogen excretion and stimulating hepatic urea... | |||
T36580 | Glucagon Receptor Antagonist Inactive Control | ||
Glucagon Receptor Antagonist Inactive Control is a Glucagon receptor antagonist that can be used in related research in the field of life sciences. Its product number is T36580 and CAS number is 362482-00-6. | |||
T11416 | Glucagon receptor antagonists-5 | Others | |
Glucagon receptor antagonists-5 is an orally bioavailable indazole-based glucagon receptor antagonist (Ki: 32 nM). It has potential for the treatment of type 2 diabetes mellitus (T2DM). | |||
TP1863 | Glucagon (19-29), human | ||
Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing e... | |||
T11415 | Glucagon receptor antagonists-3 | Others | |
Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist. | |||
T11414 | Glucagon receptor antagonists-2 | Others | |
Glucagon receptor antagonist -2 is a highly effective glucagon receptor antagonist. | |||
T11413 | Glucagon receptor antagonists-1 | Others | |
Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist. | |||
T3984 | GLP-1(7-36), amide | MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide | Glucagon Receptor |
GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-... | |||
TP1487 | Glucagon-Like Peptide (GLP) II, human | ||
Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Gluc... | |||
TP1148L | Glucagon-like peptide 1 (1-37), human acetate | Glucagon Receptor | |
Glucagon-like peptide 1 (1-37), human acetate is a highly potent the GLP-1 receptor agonist. | |||
TP1148 | Glucagon-like peptide 1 (1-37), human | HuGLP-1 | |
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on ... | |||
T82306 | Glucagon (22-29) | ||
Glucagon (22-29) acts as a partial agonist of Glucagon (19–29) and independently inhibits the calcium (Ca2+) pump in liver plasma membranes without activating adenylate cyclase [1] [2]. | |||
TP1147 | Glucagon-like peptide 1 (1-37), human TFA | HuGLP-1 TFA | |
Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor, it is a kind of pancreatic hormone synthesized by post-translational processing of proglucagon. | |||
T76326 | [Des-His1,Glu9] Glucagon | ||
[Des-His1,Glu9] Glucagon, a powerful antagonist of the glucagon receptor system, plays a crucial role in enhancing the glucose-stimulated insulin release from pancreatic islet cells. This compound is utilized in diabetes... | |||
T11845 | LGD-6972 | Glucagon Receptor | |
LGD-6972 is an antagonist of glucagon receptor. | |||
T80030 | Oxyntomodulin (bovine, porcine) (TFA) | Glucagon-37 (bovine, porcine) (TFA) | |
Oxyntomodulin (bovine, porcine) TFA is a 37-amino acid peptide hormone that functions as a glucagon-like peptide 1 (GLP-1) receptor agonist [1]. | |||
TQ0124 | BETP | Glucagon Receptor | |
BETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor). | |||
T76332 | Biotinyl-Glucagon (1-29), human, bovine, porcine | ||
Biotinyl-Glucagon (1-29), encompassing human, bovine, and porcine versions, is a biotinylated form of glucagon. This peptide hormone, synthesized by the pancreas's α-cells, elevates glucose and fatty acid levels in the b... | |||
T83550 | (Asp28)-Glucagon (1-29) (human, rat, porcine) | ||
"(Asp28)-Glucagon (1-29) (human, rat, porcine)" is an analog of glucagon with an aspartic acid (Asp) substitution at position 28, notably enhancing its aqueous solubility at physiological pH levels while retaining glucag... | |||
TP1157 | GLP-2(1-33)(human) | GLP-2 (human),Glucagon-like peptide 2 (human) | |
GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium. | |||
T80453 | GLP-1 (1-36) amide (human, rat) | Glucagon-like Peptide 1 (1-36) amide (human, rat) | |
GLP-1 (1-36) amide (human, rat) is a molecular variant of the GLP-1 (7-36) amide and has the capacity to stimulate [14C]aminopyrine accumulation in enzymatically dispersed, enriched rat parietal cells [1]. | |||
T76628 | (Met(O)27)-Glucagon (1-29) (human, rat, porcine) | ||
(Met(O)27)-Glucagon (1-29) (human, rat, porcine) is a modified version of glucagon that exhibits the same maximum glucose-synthesizing activity in rat hepatocytes as its native counterpart. However, its reduced potency i... | |||
T7364 | NNC-0640 | Glucagon Receptor | |
NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM. | |||
T82309 | GLP-1 (1-36) amide (human, rat) (TFA) | Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA) | |
GLP-1 (1-36) amide (human, rat) TFA, a molecular variant of GLP-1 (7-36) amide, can induce [14C]aminopyrine accumulation in enzymatically dispersed enriched rat parietal cells [1]. | |||
T76330 | Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide | ||
Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide, a biotin-labeled variant of glucagon-like peptide-1-(7-36), is a gastrointestinal peptide recognized for its antidiabetogenic properties, including the ability to e... | |||
T8748 | Exendin-4 acetate | Glucagon Receptor | |
Exendin-4 acetate is a 39 amino acid peptide.Exendin-4 acetate is a long-acting GLP-1 receptor agonist(IC50 = 3.22 nM). | |||
T76085 | Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human | ||
Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human, is a human GLP-1 (7-36) amide that has been biotinylated at the C-terminal. | |||
T6203 | Saxagliptin | BMS-477118,Onglyza | Proteasome , DPP-4 |
Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | |||
T19850 | Semaglutide | Glucagon Receptor | |
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor). | |||
TP2252 | GLP-1 (9-36) amide | Glucagon Receptor | |
antagonist at the human GLP-1 receptor | |||
T3967 | Exendin-4 | Exenatide,Exenatide Acetate | Glucagon Receptor |
Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours. | |||
T3422 | GRA Ex-25 | GRA-Ex-25 | Glucagon Receptor |
GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor. | |||
T9579 | GLP-1 receptor agonist 9 | Glucagon Receptor | |
1H-Benzimidazole-6-carboxylic acid is a GLP-1 receptor agonist. | |||
T0178 | Saxagliptin hydrate | Onglyza hydrate,BMS-477118 hydrate | Proteasome , DPP-4 |
Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM). | |||
T26712 | AZD-1656 | AZD 1656 | Glucokinase |
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes. | |||
TP1039 | Secretin (33-59), rat | Secretin (rat) | Glucagon Receptor |
Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide. | |||
T6876 | Liraglutide | Liraglutidum,Victoza,Liraglutida,NN2211 | Glucagon Receptor |
Liraglutide (Liraglutida) is a long-acting GLP-1 receptor agonist. | |||
TP1469 | Lixisenatide acetate (320367-13-3 free base) | Lixisenatide acetate | Glucagon Receptor |
Lixisenatide acetate is a receptor agonist similar to glucagon-like peptide-1 (glp-1) for the treatment of type 2 diabetes mellitus (T2DM). | |||
TP2100 | Avexitide | Exendin-3 (9-39) amide,Exendin (9-39) | Glucagon Receptor |
Avexitide (Exendin-3 (9-39) amide) (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor. | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
TP1376 | GLP-1(7-37) acetate(106612-94-6 free base) | GLP-1(7-37) acetate | Others , Glucagon Receptor |
Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion. | |||
T60047 | V-0219 | Glucagon Receptor | |
V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes. | |||
T8947 | Dasiglucagon acetate | dasiglucagon acetate(1544300-84-6 free base) | Others |
Dasiglucagon acetate is a novel glucagon analog for diabetic hypoglycemia therapy. Dasiglucagon acetate has demonstrated established solubility and stability in an aqueous formulation. Pharmacokinetics studies have shown... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3896 | Shanzhiside methyl ester | Glucagon Receptor | |
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. | |||
T37526 | 2-Oleoylglycerol | 2-Oleoyl Glycerol,2-OG,2-Monoolein | GPR |
2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce... | |||
T37298 | Spinacine | Endogenous Metabolite | |
Spinacine has been isolated from spinach and the roots of Panax ginseng. This conformationally constrained amino acid is a structural element in certain biologically active compounds as glucagon antagonists and angiotens... | |||
TN4997 | Serpentine | IGF-1R | |
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose up... |
Cat No. | Product Name | Species | Expression System |
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TMPY-06864 | GLP1R Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of li... | |||
TMPJ-00742 | GCG Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulate... | |||
TMPH-02628 | Cathepsin C Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function. | |||
TMPH-01386 | GLP2R Protein, Human, Recombinant (His) | Human | HEK293 Cells |
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. GLP2R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with... | |||
TMPJ-00851 | IDE Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a r... | |||
TMPH-03583 | Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc) | Staphylococcus epidermidis | E. coli |
Protease that has a low substrate specificity. Glucagon is preferentially cleaved between aromatic (Phe) and hydrophobic (Val) amino acids. Hydrolyzes casein and elastin. Extracellular elastase Protein, S. epidermidis, R... | |||
TMPY-03597 | VIP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
VIP, or vasoactive intestinal peptide, is a neuropeptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, and it exerts its actions through three G-protein-coupled receptors (PAC1, VPAC1, and VP... | |||
TMPH-01385 | GLP1R Protein, Human, Recombinant (His) | Human | HEK293 Cells |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-01384 | GLP1R Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-03301 | GLP1R Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-02676 | GLP1R Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPK-00891 | GIP Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPK-00036 | GIP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPK-00890 | GIP Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPH-02675 | GCGR Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g... | |||
TMPY-02979 | HMGN3 Protein, Human, Recombinant (His) | Human | E. coli |
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes withou... | |||
TMPY-02640 | FAM3B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and b... |