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Glucagon (1-29), bovine, human, porcine

Catalog No. T15389 CAS 16941-32-5

Synonyms: Porcine glucagon, Glucagon

Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.

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Glucagon (1-29), bovine, human, porcine Chemical Structure

Glucagon (1-29), bovine, human, porcine, CAS 16941-32-5

Pack Size	Availability	Price/USD
1 mg	5 days	$ 56.00
5 mg	5 days	$ 162.00
10 mg	5 days	$ 250.00
25 mg	5 days	$ 486.00
50 mg	5 days	$ 654.00
100 mg	5 days	Inquiry
200 mg	5 days	Inquiry

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
In vitro	Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3].
In vivo	Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4].

Synonyms	Porcine glucagon, Glucagon
Molecular Weight	3482.75
Formula	C153H225N43O49S
CAS No.	16941-32-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (14.36 mM), Sonication is recommended.

H2O: 20 mg/mL (5.74 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.

References and Literature

1. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81. 2. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60. 3. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25. 4. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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