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LGD-6972

Catalog No. T11845 CAS 1207989-09-0

LGD-6972 is an antagonist of glucagon receptor.

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LGD-6972, CAS 1207989-09-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 100.00
5 mg	In stock	$ 241.00
10 mg	In stock	$ 357.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 858.00
100 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 346.00

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Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

LGD-6972 is an antagonist of glucagon receptor.

In vivo

LGD-6972 is well tolerated at the doses tested without dose-related or clinically meaningful changes in clinical laboratory parameters. No subject experiences hypoglycaemia.LGD-6972 has linear plasma pharmacokinetics consistent with once daily dosing that is comparable in healthy and T2DM subjects.?Dose-dependent decreases in fasting plasma glucose are observed in all groups with a maximum of 3.15 mM (56.8 mg/dL) on day 14 in T2DM subjects.?LGD-6972 also reduces plasma glucose in the postprandial state.?Dose-dependent increases in fasting plasma glucagon are observed, but glucagon levels decrease and insulin levels increase after an oral glucose load in T2DM subjects.

Molecular Weight	702.9
Formula	C43H46N2O5S
CAS No.	1207989-09-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31 mg/mL (44.10 mM)

References and Literature

1. Vajda EG, et al. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2017 Jan;19(1):24-32.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Anti-Cancer Clinical Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

BETP Avexitide 3-Deoxyglucosone Orforglipron Shanzhiside methyl ester Survodutide Glucagon-like peptide 1 (1-37), human acetate Albiglutide TFA (782500-75-8 free base)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LGD-6972 1207989-09-0 GPCR/G Protein Glucagon Receptor Inhibitor hyperglycaemia GCGR Diabetes cAMP glucagon LGD 6972 LGD6972 inhibit inhibitor

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