Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 57.00 | |
2 mg | In stock | $ 81.00 | |
5 mg | In stock | $ 142.00 | |
10 mg | In stock | $ 216.00 | |
25 mg | In stock | $ 441.00 | |
50 mg | In stock | $ 649.00 | |
100 mg | In stock | $ 926.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 196.00 |
Description | GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor. |
Targets&IC50 | Glucagon (human):55 nM, Glucagon (rat):56nM |
In vitro | GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2]. |
In vivo | GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose which is caused by exogenous administration of glucagon in rat models. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenously administered glucagon, most likely due to the direct inhibition of glucagon stimulated hepatic glucose output[2]. |
Synonyms | GRA-Ex-25 |
Molecular Weight | 563.61 |
Formula | C29H36F3N3O5 |
CAS No. | 307983-31-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GRA Ex-25 307983-31-9 GPCR/G Protein Glucagon Receptor GCGR inhibit GRA Ex 25 Inhibitor GRA Ex25 GRA-Ex-25 inhibitor