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Glucagon (1-29), bovine, human, porcine hydrochloride

Catalog No. T15389L   CAS 28270-04-4
Synonyms: Porcine glucagon hydrochloride, Glucagon hydrochloride

Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon (1-29), bovine, human, porcine hydrochloride(Porcine glucagon hydrochloride) stimulates gluconeogenesis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Glucagon (1-29), bovine, human, porcine hydrochloride Chemical Structure
Glucagon (1-29), bovine, human, porcine hydrochloride, CAS 28270-04-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 79.00
5 mg In stock $ 193.00
10 mg In stock $ 289.00
25 mg In stock $ 498.00
50 mg In stock $ 729.00
100 mg In stock $ 985.00
500 mg In stock $ 1,970.00
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Purity: 98.03%
Purity: 98%
Purity: 95.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon (1-29), bovine, human, porcine hydrochloride(Porcine glucagon hydrochloride) stimulates gluconeogenesis.
In vitro Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon (100 nM) increases the phosphorylation of HNF4α. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes [3].
In vivo Glucagon (20 μg/kg) increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice [4].
Synonyms Porcine glucagon hydrochloride, Glucagon hydrochloride
Molecular Weight 3519.21
Formula C153H225N43O49S.ClH
CAS No. 28270-04-4

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81. 2. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60. 3. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25. 4. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library NO PAINS Compound Library Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Endocrinology-Hormone Compound Library Anti-Cancer Compound Library Anti-Diabetic Compound Library Peptide Compound Library Anti-Metabolism Disease Compound Library

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Keywords

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