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NNC-0640

Catalog No. T7364 CAS 307986-98-7

NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM.

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NNC-0640, CAS 307986-98-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM.
Targets&IC50	Human Glucagon Receptor:69.2 nM

Molecular Weight	573.67
Formula	C29H31N7O4S
CAS No.	307986-98-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Song G , Yang D , Wang Y , et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017. 2. Jazayeri A , Doré, Andrew S, Lamb D , et al. Extra-helical binding site of a glucagon receptor antagonist[J]. Nature, 2016.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Covalent Inhibitor Library Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Bay 55-9837 acetate HAEGTFTSD acetate(926018-45-3 free base) Secretin (33-59), rat GLP-1 receptor agonist 9 citrate NNC-0640 GLP-1(28-36)amide acetate GLP-1R Agonist DMB Teduglutide

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NNC-0640 307986-98-7 G蛋白偶联受体 Glucagon Receptor NNC0640 GCGR inhibit Inhibitor NNC 0640 inhibitor

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