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Semaglutide

Catalog No. T19850 CAS 910463-68-2

Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).

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Semaglutide, CAS 910463-68-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 213.00
5 mg	In stock	$ 463.00
10 mg	In stock	$ 663.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,370.00
100 mg	In stock	$ 1,850.00

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Purity: 99.78%

Purity: 99.56%

Purity: 96.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
Targets&IC50	GLP1R:6.2 pM(EC50)

Molecular Weight	4114
Formula	C187H291N45O59
CAS No.	910463-68-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

0.1 M HCl: 1.25 mg/mL (303.84 μM), Sonification and heating are recommended.

References and Literature

1. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284. 2. Goldenberg R M , Oren S . Semaglutide: Review and Place in Therapy for Adults with Type 2 Diabetes[J]. Canadian Journal of Diabetes, 2018:S1499267118301096-. 3. Liping Z , Lingyu Z , Lin L , et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model[J]. Neuropeptides, 2018:S0143417918300684-. 4. Rakhat Y,et al. Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice. Nutrients. 2023 Aug 28;15(17):3765. 5. Pontes-da-Silva, R.M.,et al. Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. Int J Obes 46, 21–29 (2022). 6. Withaar, C, et al. The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF. J Am Coll Cardiol Basic Trans Science. 2023 Oct, 8 (10) 1298–1314. 7. Rakipovski G, et al. The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. JACC Basic Transl Sci. 2018 Nov 21;3(6):844-857.

Related compound libraries

This product is contained In the following compound libraries：

Approved Drug Library Peptide Compound Library Anti-Diabetic Compound Library GPCR Compound Library NO PAINS Compound Library Anti-Metabolism Disease Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

L-168049 GLP-1R modulator C5 Orforglipron Exendin-4 acetate Cotadutide acetate Semaglutide Acetate Glucagon-like peptide 1 (1-37), human acetate Retatrutide sodium salt

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Semaglutide 910463-68-2 GPCR/G Protein Glucagon Receptor Inhibitor GCGR inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.