g-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15364	G-1		Estrogen Receptor/ERR , GPR
	G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).		Estrogen Receptor/ERR , GPR
T67755	Protein kinase G inhibitor-1		PKA
	Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.		PKA
T27066	Prostaglandin G/H synthase 1 inhibitor	CP74006,CP 74006,2-Amino-N-(4-chlorophenyl)benzamide	Others
	Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.		Others
T8640	G6PDi-1		Dehydrogenase
	G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.		Dehydrogenase
T4661	PKG drug G1		PKA
	PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.		PKA
T8328	STING agonist-1	G10	Virus Protease , STING
	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.		Virus Protease , STING
T67900	PKM2 inhibitor G		PKM
	PKM2 inhibitor G is a inhibitor of pyruvate kinase.		PKM
T6843	GDC-0623	G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis , MEK
	GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.		Apoptosis , MEK
TN1555	Platycoside G1	Deapi-platycoside E	Others
	Platycoside G1 (Deapi-platycoside E) may have anti-inflammatory effects.		Others
T8818	TC-G 1005		GPCR19
	TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.		GPCR19
T7428	SBI-115		GPCR19
	SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5		GPCR19
TN6985	Anhydronotoptol	4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one	NO Synthase
	Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangwu, is a potent inhibitor of nitric oxide production, inhibi...		NO Synthase
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T4083	BAR501	BAR 501	GPCR19
	BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).		GPCR19
TQ0252	BAR502		FXR , GPCR19 , Autophagy
	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).		FXR , GPCR19 , Autophagy
T4352	SB756050	SB-756050,SB 756050	GPCR19
	SB756050 is a specific TGR5 agonist.		GPCR19
T4288	HVEGF-IN-1		VEGFR
	hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.		VEGFR
TP1543L	G280-9 acetate(156761-76-1 free base)		Others
	G280-9 acetate is a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows ...		Others
T5077	Deoxycholic acid sodium salt	Sodium deoxycholate,Sodium Desoxycholate	Endogenous Metabolite , GPCR19
	Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.		Endogenous Metabolite , GPCR19
T25199	Cafaminol	Cafaminolum,G1,G-1,G 1
	Cafaminol (methylcoffanolamine) is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant.