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PKG drug G1

PKG drug G1
PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
Catalog No. T4661Cas No. 374703-78-3
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Purity:99.41%
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PKG drug G1

Catalog No. T4661Cas No. 374703-78-3
PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$33In Stock
5 mg$51In Stock
10 mg$79In Stock
25 mg$158In Stock
50 mg$239In Stock
100 mg$363In Stock
500 mg$855In Stock
1 mL x 10 mM (in DMSO)$56In Stock
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Product Introduction

Bioactivity
Description
PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
In vivo
The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys. The metabolism of Asimadoline is rapid and appears similar in animals and man. Asimadoline has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels
Animal Research
Mice constitutively expressing PKG Iα Cys42Ser are generated on a pure C57BL/6 background. Age-matched and. body weight–matched WT or PKG Iα Cys42Ser KI male mice are used in all studies. Blood pressure and heart rate are. assessed by radio telemetry in conscious freely moving mice. Alzet osmotic mini-pumps are used to deliver. angiotensin II at 1.1 mg/kg per day in some studies. PKG drug G1 is delivered intraperitoneally (3.7-14.8 mg/kg) or. orally (20 mg/kg) in some studies. To deliver PKG drug G1 orally, without stress or risk of dislodging the telemetric. probe catheter, it is provided suspended in water and set in gelatin flavored with sodium saccharin.
Chemical Properties
Molecular Weight257.31
FormulaC13H11N3OS
Cas No.374703-78-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16.67 mg/mL (64.77 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8864 mL19.4318 mL38.8636 mL194.3181 mL
5 mM0.7773 mL3.8864 mL7.7727 mL38.8636 mL
10 mM0.3886 mL1.9432 mL3.8864 mL19.4318 mL
20 mM0.1943 mL0.9716 mL1.9432 mL9.7159 mL
50 mM0.0777 mL0.3886 mL0.7773 mL3.8864 mL

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