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SB756050

Catalog No. T4352 CAS 447410-57-3

Synonyms: SB-756050, SB 756050

SB756050 is a specific TGR5 agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SB756050, CAS 447410-57-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 288.00
500 mg	In stock	$ 686.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 100%

Purity: 98.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SB756050 is a specific TGR5 agonist.
In vitro	TGR5 is a potential target for the therapy of type 2 diabetes (T2D). Thus, SB756050 is used in phase 1clinical trials for the treatment of type 2 diabetes.
In vivo	SB756050 is well‐tolerated with nonlinear pharmacokinetics. It shows dose‐proportional increase in plasma exposure above 100 mg, and has no marked changes in exposure when co‐administered with sitagliptin. SB756050 has highly variable pharmacodynamic effects both within between doses and dose groups, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 t sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.

Synonyms	SB-756050, SB 756050
Molecular Weight	500.59
Formula	C21H28N2O8S2
CAS No.	447410-57-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library ReFRAME Related Library Anti-Cancer Compound Library Target-Focused Phenotypic Screening Library Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-Diabetic Compound Library GPCR Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

BAR 501 impurity BAR502 SBI-115 Deoxycholic acid BAR501 TC-G 1005 TGR5 Receptor Agonist Hyodeoxycholic acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SB756050 447410-57-3 GPCR/G Protein GPCR19 G protein-coupled Bile Acid Receptor 1 inhibit SB-756050 TGR5 SB 756050 Inhibitor GPBAR1 G-protein coupled receptor 19 inhibitor

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