cdk7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40264	CDK7-IN-7	CDK7-IN-7
	CDK7-IN-7, a highly potent and selective inhibitor of CDK7 kinase, exhibits remarkable activity with an IC50 of less than 50 nM.
T39943	CDK7-IN-6	CDK7-IN-6
	CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. Thi...
T39372	CDK7-IN-1	CDK7-IN-1
	CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound ...
T39247	CDK7-IN-5	CDK7-IN-5
	CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).
T40353	CDK7/9-IN-1	CDK7/9-IN-1
	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency ag...
T36038	SY-5609	CDK7-IN-3	CDK
	SY-5609 is a selective and noncovalent inhibitor of CDK7(KD = 0.065 nM) with antitumor activity and inhibits apoptosis.		CDK
T7296	THZ2	CDK7-IN-1	CDK
	THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).		CDK
T39864	CDK7-IN-2 hydrochloride hydrate	CDK7-IN-2 hydrochloride hydrate
	CDK7-IN-2 hydrochloride hydrate (Example 6) is a highly effective and specific inhibitor of the CDK7 enzyme. This compound exhibits significant anti-cancer properties.
T3664	THZ1	CDK7 inhibitor,THZ1 2HCl	CDK
	THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor.		CDK
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:1...
T79169	CDK7-IN-22		CDK
	CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].		CDK
T75121	CDK7-IN-21
	CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .
T63410	CDK7-IN-17
	CDK7-IN-17 is a pyrimidine-derived compound and a potent inhibitor of CDK7. CDK7-IN-17 has shown research potential for a variety of cancers, particularly those with dysregulated transcription.
T63108	CDK7-IN-14
	CDK7-IN-14 is a pyrimidine-derived compound that is a potent inhibitor of CDK7. CDK7-IN-14 has the potential to be investigated in a variety of cancers, particularly those with transcriptional dysregulation.
T63381	CDK7-IN-8
	CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.
T63301	CDK7-IN-18
	CDK7-IN-18 is a pyrimidine-derived compound that is a potent inhibitor of CDK7. CDK7-IN-18 exhibits potential for research in a variety of cancers, particularly those with dysregulated transcription.
T79881	CDK7-IN-25		CDK
	CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].		CDK
T62791	CDK7-IN-16
	CDK7-IN-16 (Compound 9) is a potent inhibitor of CDK 7 (IC50: 1-10 nM). CDK7-IN-16 can be used in research against cancer, particularly cancers with transcriptional abnormalities.
T63724	CDK7-IN-10
	CDK7-IN-10 is a CDK7 inhibitor (IC50<100 nM). CDK7-IN-10 inhibits kinase activity and has the potential to inhibit cell growth and induce apoptosis.
T61922	CDK7-IN-12
	CDK7-IN-12 is an effective CDK7 inhibitor and plays a key role in regulating transcription and cell cycle. CDK7-IN-12 can effectively inhibit the proliferation of malignant tumors in vitro and in vivo. CDK7-IN-12 has res...
T63217	CDK7-IN-15
	CDK7-IN-15 is a pyrimidine-derived compound and a potent inhibitor of CDK7. CDK7-IN-15 has the potential to be investigated in a variety of cancers, particularly those with dysregulated transcription.
T62759	CDK7-IN-13
	CDK7-IN-13 is a pyrimidine-derived compound that is a potent inhibitor of CDK7. CDK7-IN-13 has the potential to be investigated in a variety of cancers (particularly those with dysregulated transcription).
T63368	CDK7-IN-2
	CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is involved in transcription initiation using phosphorylation of the Rbpl subunit of RNA polymerase II (RNAPII), which is associated with temporal control of cell cycle and t...
T73163	CDK7-IN-20
	CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK...
T82227	HDAC1/CDK7-IN-1		HDAC
	HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell...		HDAC
T62926	CDK7/12-IN-1
	CDK7/12-IN-1 is a selective inhibitor of CDK7/12, acting on CDK7 (IC50: 3 nM) and CDK 12 (IC50: 277 nM). Inhibition of CDK7 and CDK12 is an effective inhibitor of tumour growth.
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T13044	Mevociclib	SY-1365	CDK
	Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.		CDK
T10898	Samuraciclib hydrochloride	ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis , CDK
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...		Apoptosis , CDK
T4051	LDC4297	LDC044297	CDK , HSV
	LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.		CDK , HSV
T4417	LDC-4297 HCl (1453834-21-3(free base))		CDK
	LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.		CDK
T6162	BS-181 hydrochloride	BS-181 HCl	CDK
	BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.		CDK
T35332	THZ1 2HCl	THZ1 2HCl,THZ1 Dihydrochloride	CDK
	THZ1 2HCl (THZ1 Dihydrochloride) is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a variety of cancer cell lines.		CDK
TQ0060	LY2857785		Apoptosis , CDK
	LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).		Apoptosis , CDK
T6049	SNS-032	SNS032,BMS-387032	Apoptosis , GSK-3 , CDK
	SNS-032 (BMS-387032) is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and no effect on CDK6.		Apoptosis , GSK-3 , CDK
T22440	TP-353	EOS-61973	CDK
	TP-353 (EOS-61973) is a CDK7 inhibitor.		CDK
T2095	Seliciclib	Roscovitine,R-roscovitine,CYC202	CDK
	Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).		CDK
T9078	LY3405105	1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester	CDK
	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.		CDK
T39752	CDK12-IN-2	CDK12 inhibitor 2,CDK12-IN-2	CDK
	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD...		CDK
T6837	Flavopiridol	L868275,Alvocidib,NSC 649890 HCl,HMR-1275	Apoptosis , HIV Protease , CDK , Autophagy
	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun...		Apoptosis , HIV Protease , CDK , Autophagy
T6205	AT7519		Apoptosis , GSK-3 , CDK
	AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.		Apoptosis , GSK-3 , CDK
T6312	R547	Ro 4584820	Apoptosis , GSK-3 , PKA , CDK
	R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.		Apoptosis , GSK-3 , PKA , CDK
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T13153	THZ1-R		CDK
	THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).		CDK
T1947	BS-181	BS 181	Apoptosis , CDK
	BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.		Apoptosis , CDK
T13367	YKL-5-124 TFA (1957203-01-8 free base)	YKL-5-124 TFA	Others
	YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).		Others
T39456	IV-361
	IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T24643	YKL-1-116	YKL 1 116,YKL1116
	YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.

Compounds

CDK7-IN-7

T40264

Synonym: CDK7/9-IN-1

CDK7-IN-2 hydrochloride hydrate

T39864

Synonym: CDK7-IN-2 hydrochloride hydrate

Target:

THZ1

T3664

Synonym: CDK7 inhibitor,THZ1 2HCl

Samuraciclib hydrochloride

T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

LDC-4297 HCl (1453834-21-3(free base))

Synonym: THZ1 2HCl,THZ1 Dihydrochloride

Target: Apoptosis, CDK

SNS-032

T6049

Synonym: SNS032,BMS-387032

Target: Apoptosis, GSK-3, CDK

Synonym: Roscovitine,R-roscovitine,CYC202

Target: CDK

LY3405105

T9078

Synonym: 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester

Target: CDK

CDK12-IN-2

T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

Flavopiridol

T6837

Synonym: L868275,Alvocidib,NSC 649890 HCl,HMR-1275

Target: Apoptosis, HIV Protease, CDK, Autophagy

AT7519

T6205

Synonym:

Target: Apoptosis, GSK-3, CDK

R547

T6312

Synonym: Ro 4584820

Target: Apoptosis, GSK-3, PKA, CDK

RGB-286638 free base

T2378

Synonym:

Target: GSK-3, MEK, JAK, CDK

CGP60474

T14943

Synonym:

Target: VEGFR, CDK, PKC

Target: Apoptosis, CDK

YKL-5-124 TFA (1957203-01-8 free base)

T13367

Synonym: YKL-5-124 TFA

Synonym: YKL 1 116,YKL1116

Target:

Cat No.	Product Name	Species	Expression System
TMPH-01172	CDK7 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-01173	CDK7 Protein, Human, Recombinant	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPY-04449	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 118.8 kDa and the accession number is P50613&P51946&P51948.
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...

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Compounds

Recombinant Proteins

Compounds

Recombinant Proteins