Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 227.00 | |
10 mg | Inquiry | $ 386.00 | |
50 mg | Inquiry | Inquiry | |
100 mg | Inquiry | Inquiry | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 314.00 |
Description | YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively). |
Targets&IC50 | CDK7-CyclinH-MAT1:9.7 nM, CDK7:53.5 nM, CDK9:3020 nM, CDK2:1300 nM |
In vitro | In G1- and G2/M-phase cells and a corresponding loss of S-phase cells, YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase . YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion. |
Synonyms | YKL-5-124 TFA |
Molecular Weight | 629.63 |
Formula | C30H34F3N7O5 |
CAS No. | T13367 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (158.82 mM)
You can also refer to dose conversion for different animals. More
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YKL-5-124 TFA (1957203-01-8 free base) T13367 Others YKL5124 TFA (1957203018 free base) YKL 5 124 TFA (1957203 01 8 free base) 1957203-01-8 YKL-5-124 TFA 1957203-01-8 free base inhibitor inhibit