by-27 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10638	BY27		Epigenetic Reader Domain
	BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth.		Epigenetic Reader Domain
T1276	Danofloxacin mesylate	CP 76136-27	DNA/RNA Synthesis , Antibacterial , Antibiotic
	Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.		DNA/RNA Synthesis , Antibacterial , Antibiotic
T8301	Amaranth	Acid Red 27	Others
	Amaranth (Acid Red 27) as a potential component of lifestyle modification to improve cardiovascular risk profiles by modifying cardiovascular risk factors such as cholesterol, diabetes, and hypertension.		Others
T39321	CC-99677	CC99677,Gamcemetinib,CC 99677	HSP , MAPK
	CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock pro...		HSP , MAPK
TN1222	26-Deoxyactein	27-Deoxyactein,23-epi-26-Deoxyactein	NOS , CDK , NO Synthase
	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...		NOS , CDK , NO Synthase
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
TP1936L1	RFRP3(human) acetate(311309-27-0 free base)		Neuropeptide Y Receptor
	RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced produ...		Neuropeptide Y Receptor
T0839L	S-(+)-Ketoprofen	RP-19583,Dexketoprofen,(S)-(+)-Ketoprofen,(S)-Ketoprofen	COX
	S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygen...		COX
T24146	HOCPCA
	HOCPCA is an effective and selective ligand for the GHB binding sites that acts by binding with 27 times better affinity than GHB itself and crossing the blood-brain barrier in vitro and in vivo.
T39889	Antitumor agent-23
	Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respe...
T37206	CCK (27-33) (non-sulfated)
	CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]n...
T80148	GRP (14-27) (human, porcine, canine)		Bombesin Receptor
	GRP (14-27) (human, porcine, canine) functions as a ligand for bombesin receptors, with its specific binding being inhibited by GTP and GDP, while GMP does not affect it [1].		Bombesin Receptor
T61141	Antitubercular agent-27
	Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37R...
T61447	CXCR2 antagonist 4
	CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. ...
T35590	Graphislactone A
	Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. olivacea. It exhibits dose-dependent scavenging activity against DPPH radicals and metal ion-dependent hydroxyl radicals in vitro. Graphislact...
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)		PACAP
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres...		PACAP
T63952	GRPR antagonist-2
	GRPR antagonist-2 is a potent antagonist of the gastrin-releasing peptide receptor (GRPR) and exhibits anticancer effects by being cytotoxic to certain cancer cells (able to act on HGC-27 cells (IC50: 0.77 μM) and Pan02 ...
T80515	β-Endorphin (1-27) (human)		Opioid Receptor
	β-Endorphin (1-27) (human) is an opioid antagonist that selectively binds to μ-, δ-, and κ-opioid receptors, with dissociation constants (Kis) of 5.31, 6.17, and 39.82 nM, respectively. It inhibits analgesia induced by b...		Opioid Receptor
T20016	Diuron	HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron
	Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,...
T37177	Norcholic Acid
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of met...