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BY27

Catalog No. T10638 CAS 2247236-59-3

BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth.

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BY27, CAS 2247236-59-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 2,270.00
50 mg	8-10 weeks	$ 2,980.00
100 mg	8-10 weeks	$ 4,000.00

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Purity: 99.40%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth.
Targets&IC50	BRD3 BD2:5.3 nM (Ki), BRD2 BD1:45 nM (Kd), BRD4 BD1:26 nM (Kd), BRD3 BD1:12 nM (Kd), BRD4 BD2:3.5 nM (Kd), BRD2 BD2:3.1 nM (Ki), BRD2 BD1:95.5 nM (Ki), BRD3 BD1:77.9 nM (Ki), BRD2 BD2:1.2 nM (Kd), BRDT BD1:64 nM (Kd), BRD4 BD1:80 nM (Ki), BRD4 BD2:7.3 nM (Ki), BRD3 BD2:2.6 nM (Kd), BRDT BD2:3 nM (Kd)

Molecular Weight	404.89
Formula	C22H21ClN6
CAS No.	2247236-59-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chen D, et al. Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur J Med Chem. 2019 Aug 21;182:111633.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BY27 2247236-59-3 Chromatin/Epigenetic Epigenetic Reader Domain BY-27 BY 27 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.