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Diuron

Name: Diuron
Brand: TargetMol
SKU: T20016
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20016Cas No. 330-54-1

Alias Seduron, Marmer, Lucenit, Karmex, HW 920, Dirurol

Diuron is an orally active benzoylurea herbicide against annual, perennial broadleaf weeds, and grass weeds. Diuron inhibits the production of ATP and NADH, thereby impairing plant photosynthesis, and also increases ROS production and promotes DMBA/BBN-induced bladder cancer development.

Diuron

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Purity: 99.68%

Catalog No. T20016Alias Seduron, Marmer, Lucenit, Karmex, HW 920, DirurolCas No. 330-54-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$70	-	In Stock
10 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Diuron is an orally active benzoylurea herbicide against annual, perennial broadleaf weeds, and grass weeds. Diuron inhibits the production of ATP and NADH, thereby impairing plant photosynthesis, and also increases ROS production and promotes DMBA/BBN-induced bladder cancer development.
In vitro	Diuron (100 nM-200 μM, 24-72 h) was used to treat BeWo cells and MCF-7 cells. It was found that Diuron could significantly increase the production of ROS in BeWo cells and reduce their cell viability. At the same time, Diuron could significantly increase the production of ROS and induce DNA damage in MCF-7 cells. [1]
In vivo	Diuron (25-2500 ppm, oral, 20 weeks) treatment of Wistar rats can induce hyperplasia of the bladder and renal pelvis urothelium in a dose-response relationship. [5]
Synonyms	Seduron, Marmer, Lucenit, Karmex, HW 920, Dirurol

Chemical Properties

Molecular Weight	233.10
Formula	C₉H₁₀Cl₂N₂O
Cas No.	330-54-1
Smiles	O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)C
Relative Density.	1.48 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (858 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2900 mL	21.4500 mL	42.9000 mL	214.5002 mL
5 mM	0.8580 mL	4.2900 mL	8.5800 mL	42.9000 mL
10 mM	0.4290 mL	2.1450 mL	4.2900 mL	21.4500 mL
20 mM	0.2145 mL	1.0725 mL	2.1450 mL	10.7250 mL
50 mM	0.0858 mL	0.4290 mL	0.8580 mL	4.2900 mL
100 mM	0.0429 mL	0.2145 mL	0.4290 mL	2.1450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc