2-ag — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4694	AG-1557 hydrochloride (189290-58-2(free base))		EGFR , HER
	AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).		EGFR , HER
T6266	PP2	AGL 1879,AG 1879,AGL 1879	EGFR , Tyrosine Kinases , JAK , Src
	PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.		EGFR , Tyrosine Kinases , JAK , Src
T7493	AG-13958	AG-013958	VEGFR
	AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.		VEGFR
T1088	Repaglinide	AG-EE 388 ZW,AG-EE 623ZW	Potassium Channel , PPAR
	Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare...		Potassium Channel , PPAR
T13238	Tyrphostin AG1433	SU1433,AG1433	VEGFR , PDGFR
	Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).		VEGFR , PDGFR
T22253	AG-120 (racemic)		Dehydrogenase
	AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic activity.		Dehydrogenase
T4052	KML29		Lipase
	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effective...		Lipase
T29372	2-Pyridineacetamide, 5-ethylthio-	AG-41,AG 41,AG41
	2-Pyridineacetamide, 5-ethylthio- is a biochemical.
T29373	2-Pyridineacetamide, 5-methylthio-	AG 42,AG-42 AG42
	2-Pyridineacetamide, 5-methylthio- is a biochemical.
T22456	Voreloxin hydrochloride	SNS-595 hydrochloride,Vosaroxin	Apoptosis , Topoisomerase
	Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.		Apoptosis , Topoisomerase
T4554	AG 1406		VEGFR
	AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.		VEGFR
T2346	Enasidenib	AG-221	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T11724	JNJ-42226314		Lipase
	JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ...		Lipase
T14137	AG 1295		PDGFR
	AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4].		PDGFR
T4205	AG-494	Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR , CDK
	AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.		EGFR , CDK
T1452	Axitinib	AG-013736	VEGFR , PDGFR , c-Kit
	Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.		VEGFR , PDGFR , c-Kit
T3617	Ivosidenib	AG-120	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi...		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T4092	AG126	Tyrphostin AG126,AG 126	ERK , COX
	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expres...		ERK , COX
T6554	JZL 184	JZL184	Lipase
	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.		Lipase
T5815	MJN110	Cravatt Reagent	Lipase
	MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.		Lipase