Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 < 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; <50 μM, AEA).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 81.00 | |
25 mg | In stock | $ 175.00 | |
50 mg | In stock | $ 257.00 | |
100 mg | In stock | $ 379.00 | |
500 mg | In stock | $ 892.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 60.00 |
Description | KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA). |
Targets&IC50 | MAGL (human):5.9 nM, MAGL (rat):43 nM, MAGL (mouse):15 nM, 2-AG:2.5 nM, AEA:>50 μM |
In vivo | DprE1-IN-2 has efficacy in a rodent model of tuberculosis. |
Molecular Weight | 549.42 |
Formula | C24H21F6NO7 |
CAS No. | 1380424-42-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (91 mM)
You can also refer to dose conversion for different animals. More
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KML29 1380424-42-9 Metabolism Lipase LPS KML 29 allodynia Monoacylglycerol lipase MAGL inhibit 2-AG Inhibitor HFIP KML-29 inhibitor