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Ivosidenib

Catalog No. T3617 CAS 1448347-49-6

Synonyms: 艾伏尼布, AG-120

Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.

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Ivosidenib, CAS 1448347-49-6

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Purity: 98%

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Description	Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Targets&IC50	IDH1R132H:12 nM
In vitro	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1].
Cell Research	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)

Synonyms	艾伏尼布, AG-120
Molecular Weight	582.97
Formula	C28H22ClF3N6O3
CAS No.	1448347-49-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 100 mg/mL (171.54 mM)

H2O: <1 mg/mL

DMSO: 39 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Erica Hansen, et al. Blood. 2104, 124:3734.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Cancer Cell Differentiation Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Glutamine Metabolism Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Ivosidenib 1448347-49-6 代谢 Dehydrogenase Isocitrate Dehydrogenase (IDH) AG 120 AG120 inhibit AG-120 Inhibitor inhibitor

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