Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Description | Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. |
Targets&IC50 | IDH1R132H:12 nM |
In vitro | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1]. |
Cell Research | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference) |
Synonyms | 艾伏尼布, AG-120 |
Molecular Weight | 582.97 |
Formula | C28H22ClF3N6O3 |
CAS No. | 1448347-49-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 100 mg/mL (171.54 mM)
H2O: <1 mg/mL
DMSO: 39 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ivosidenib 1448347-49-6 代谢 Dehydrogenase Isocitrate Dehydrogenase (IDH) AG 120 AG120 inhibit AG-120 Inhibitor inhibitor