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JNJ-42226314

Catalog No. T11724 CAS 1252765-13-1

JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.

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JNJ-42226314, CAS 1252765-13-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 183.00
25 mg	In stock	$ 369.00
50 mg	In stock	$ 595.00
100 mg	In stock	$ 953.00
500 mg	In stock	$ 1,880.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.
In vitro	After treatment with PF-3845 ( 1 or 10 μM ), JZL-184 ( 1 or 10 μM ), JNJ-42226314 ( 1 or 10 μM ) or carrier ( DMSO ), JNJ-42226314 was selectively analyzed by competitive ABPP. The results showed that JNJ-42226314 had high selectivity for MAGL [1].
In vivo	In male C57Bl/6 mice weighing 20-30g and male Sprague-Dawley rats weighing 300-400g, treatment with JNJ-42226314 (3 mg/kg and 30 mg/kg; i.p.; 120 min) dose-dependently elevated hippocampal 2-AG levels in vivo[1].

Molecular Weight	489.56
Formula	C26H24FN5O2S
CAS No.	1252765-13-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (204.26 mM), Sonification is recommended.

References and Literature

1. Wyatt RM, et al.Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor.J Pharmacol Exp Ther. 2019 Dec 9.

Related Products

Related compounds with same targets

MJN110 KML29 JZL 184 WWL70 PF-06795071 MAGL-IN-4 URB602 AA38-3

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Keywords

JNJ-42226314 1252765-13-1 Metabolism Lipase JNJ 42226314 JNJ42226314 inhibitor inhibit

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