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AG126

Catalog No. T4092 CAS 118409-62-4

Synonyms: Tyrphostin AG126, AG 126

AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 < 100 μM).

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AG126, CAS 118409-62-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 233.00
50 mg	In stock	$ 346.00
100 mg	In stock	$ 513.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 98.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

GFRK:> 100 μM, GFRK:450 μM, ERK2 (p42):25-50 μM, ERK1 (p44):25-50 μM

Synonyms	Tyrphostin AG126, AG 126
Molecular Weight	215.16
Formula	C10H5N3O3
CAS No.	118409-62-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (464.75 mM), Sonication and heating are recommended.

References and Literature

1. Novogrodsky, A.,Vanichkin, A.,Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264(5163), 1319-1322 (1994). 2. Hanisch, U.K.,Prinz, M.,Angstwurm, K., et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. European Journal of Immunology 31, 2104-2115 (2001).

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Apoptosis Compound Library Stem Cell Differentiation Compound Library Glutamine Metabolism Compound Library Angiogenesis related Compound Library Covalent Inhibitor Library Anti-Ovarian Cancer Compound Library Anti-Cardiovascular Disease Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

Capillarisin (R)-VX-11e ERK1/2 inhibitor 1 ERK5-IN-6 Bohemine AX-15836 Meranzin hydrate (E/Z)-BIX02188

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AG126 118409-62-4 Immunology/Inflammation MAPK Neuroscience ERK COX Tyrphostin AG-126 Extracellular signal regulated kinases Tyrphostin AG 126 BRMECs Inhibitor inhibit AG-126 Tyrphostin AG126 ARPE-19 AG 126 inhibitor

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