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Se-Methylselenocysteine

Catalog No. T7727 CAS 26046-90-2

Synonyms: Se MSC, SeMCys, MSeC, Se-MSC, SeMSC

Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Se-Methylselenocysteine Chemical Structure

Se-Methylselenocysteine, CAS 26046-90-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 332.00
200 mg	In stock	$ 498.00

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Purity: 99.49%

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Description	Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
In vitro	Se-Methylselenocysteine displayed strong inhibitory effects on cell proliferation and viability of SKOV-3 cells in dose and time dependent manners and induced apoptosis. Pretreatment of cells with the caspase inhibitors (z-VAD-fmk and DEVD-CHO) prevented Se-Methylselenocysteine-induced apoptosis. In late stage of apoptosis, p18kDa fragment of Bax was generated with the down-regulation of the expressions of survivin, X-linked inhibitor of apoptosis protein, and human inhibitor of apoptosis protein 1 following Se-Methylselenocysteine treatment. Pre-treatments of z-VAD-fmk and the calpain inhibitor, calpeptin inhibited Bax cleavage. Taken together, the chemopreventive effects of Se-Methylselenocysteine may be related in part to the caspase-3 activation, the down-regulation of IAP family proteins, and Bax cleavage mediated by caspase-dependent calpain activation[2].
In vivo	AD mice are treated with Se-Methylselenocysteine (0.75 mg kg-1 BW per day) in their drinking water for 10 months. Results reveal that Se-Methylselenocysteine 1) reduces oxidative stress and neuro-inflammation; 2) modulates the distribution and levels of several metal ions; 3) decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1); and 4) attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[4].

Synonyms	Se MSC, SeMCys, MSeC, Se-MSC, SeMSC
Molecular Weight	182.08
Formula	C4H9NO2Se
CAS No.	26046-90-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 83.33 mg/mL (457.66 mM)

References and Literature

1. Yao Z, Zhang Y, Li H, Deng Z, Zhang X. Synergistic effect of Se-methylselenocysteine and vitamin E in ameliorating the acute ethanol-induced oxidative damage in rat. J Trace Elem Med Biol. 2015 Jan;29:182-7. doi: 10.1016/j.jtemb.2014.08.004. PubMed PMID: 25213679. 2. Yang H, Jia X. Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: acute toxicity, genotoxicity and subchronic toxicity. Regul Toxicol Pharmacol. 2014 Dec;70(3):720-7. doi: 10.1016/j.yrtph.2014.10.014. PubMed PMID: 25444999. 3. Avila FW, Yang Y, Faquin V, Ramos SJ, Guilherme LR, Thannhauser TW, Li L. Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified Brassica sprouts. Food Chem. 2014 Dec 15;165:578-86. doi: 10.1016/j.foodchem.2014.05.134. PubMed PMID: 25038715. 4. Cao S, Durrani FA, Tóth K, Rustum YM. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. doi: 10.1038/bjc.2014.85. PubMed PMID: 24619073; PubMed Central PMCID: PMC3974093.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Microbial Natural Product Library RO5 Drug-like Natural Product Library Anti-Cancer Compound Library Antioxidant Compound Library Orally Active Compound Library PPI Inhibitor Library

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Keywords

Se-Methylselenocysteine 26046-90-2 Apoptosis Proteases/Proteasome IAP Caspase BCL caspase-3 A253 neck SKOV-33 FaDu chemopreventive cancer Se MSC cells SeMCys head MSeC Inhibitor SeMethylselenocysteine orally Methylselenocysteine Se Methylselenocysteine Se-MSC inhibit SeMSC inhibitor

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