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Dihydromyricetin

Catalog No. T2998   CAS 27200-12-0
Synonyms: Ampelopsin, Ampeloptin

Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.

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Dihydromyricetin Chemical Structure
Dihydromyricetin, CAS 27200-12-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 55.00
25 mg In stock $ 73.00
50 mg In stock $ 89.00
100 mg In stock $ 139.00
500 mg In stock $ 346.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 96.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
Targets&IC50 mTOR:48 μM
Source
Synonyms Ampelopsin, Ampeloptin
Molecular Weight 320.25
Formula C15H12O8
CAS No. 27200-12-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 60 mg/mL (187.4 mM)

DMSO: 60 mg/mL (187.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Zhang YS, et al. Yao Xue Xue Bao, 2003, 38(4), 241-244. 2. Shen Y, et al. J Neurosci, 2012, 32(1), 390-401. 3. Liu H, Ye F, Sun Q, et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro[J] . Medicinal Chemistry. 2021, 36(1): 497-503.

TargetMolCitations

1. Xiao T, Wei Y, Cui M, et al. Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis. Phytomedicine. 2021: 153704. 2. Liu H, Ye F, Sun Q, et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2021, 36(1): 497-503 3. Li J, Xiao X, Ou Y, et al.USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer.Cancer Communications.2023 4. He H, Huang Y, Zhang X, et al.Supercritical fluid coating of flavonoids on excipients enhances drug release and antioxidant activity.International Journal of Pharmaceutics.2023: 122593.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Colorectal Cancer Compound Library Anti-infective Natural Product Library Anti-Fibrosis Compound Library Ion Channel Inhibitor Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library

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Keywords

Dihydromyricetin 27200-12-0 Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Neuroscience PI3K/Akt/mTOR signaling Influenza Virus mTOR DNA/RNA Synthesis GABA Receptor inhibit Ampelopsin Mammalian target of Rapamycin Ampeloptin Inhibitor inhibitor

 

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