vascular — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T9724	VEGFR2-IN-2		Others
	VEGFR2-IN-2 has anti-inflammatory and analgesic activities.		Others
T12598	Pz-1		VEGFR , c-RET
	Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.		VEGFR , c-RET
T8213	Isolinderalactone		NOS , STAT
	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.		NOS , STAT
TQ0321	BIBF 1202		VEGFR
	BIBF 1202 is a VEGFR2 kinase inhibitor (IC50: 62 nM).		VEGFR
T2446	KI8751		EGFR , VEGFR , FGFR , PDGFR , c-Kit
	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.		EGFR , VEGFR , FGFR , PDGFR , c-Kit
T9979	VEGFR-2-IN-29		VEGFR
	VEGFR-2-IN-29 is a VEGFR2 inhibitor.		VEGFR
T8206	Cycleanine		Others
	Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.		Others
T14349	Auristatin F		Microtubule Associated
	Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.		Microtubule Associated
T2456	Tivozanib	AV-951,KRN951	VEGFR , PDGFR , Ephrin Receptor
	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.		VEGFR , PDGFR , Ephrin Receptor
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T6012	SAR131675	SAR 131675	VEGFR
	SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.		VEGFR
T17280	(Z)-Guggulsterone		Apoptosis , VEGFR , Akt
	(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.		Apoptosis , VEGFR , Akt
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T4A2456	Gamabufotalin	Gamabufagin	COX
	1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.		COX
T2419	BMS-794833		VEGFR , c-Met/HGFR
	BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.		VEGFR , c-Met/HGFR
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
TQ0041	Ningetinib Tosylate		VEGFR , c-Met/HGFR , TAM Receptor
	Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.		VEGFR , c-Met/HGFR , TAM Receptor
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T8157	Centhaquin	PMZ-2010,Centhaquine	Others
	Centhaquin (Centhaquine)e is an adrenergic receptor potentially for the treatment of postoperative pain and for the resuscitation of hypovolemic shock		Others