spindle — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3434	BAY1217389		Kinesin
	BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).		Kinesin
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
T14765	BOS-172722		Kinesin
	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).		Kinesin
T2689	AZ3146	AZ 3146	Kinesin
	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.		Kinesin
T12237	NMS-P715		Casein Kinase , Kinesin , MELK , MAPK
	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).		Casein Kinase , Kinesin , MELK , MAPK
T2313	MPI-0479605		Apoptosis , Kinesin
	MPI-0479605 is an ATP competitive and selective inhibitor.		Apoptosis , Kinesin
T16130	Mps1-IN-3		Kinesin
	Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).		Kinesin
T8487	Empesertib	BAY 1161909	Kinesin
	Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.		Kinesin
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T8492	BO-264		Apoptosis , FGFR
	BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).		Apoptosis , FGFR
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T1270	Vincristine sulfate	Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate	Apoptosis , Microtubule Associated
	Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.		Apoptosis , Microtubule Associated
T2255	SB-743921 hydrochloride	SB743921 HCl,SB743921	Kinesin , KSP
	SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).		Kinesin , KSP
T0190	Vinorelbine	KW-2307 base	Microtubule Associated
	Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.		Microtubule Associated
T9831	MKC-1	Ro-31-7453	Apoptosis , Akt , Microtubule Associated , mTOR
	MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...		Apoptosis , Akt , Microtubule Associated , mTOR
T2103	Ispinesib	CK0238273,SB-715992	Apoptosis , Kinesin , KSP
	Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.		Apoptosis , Kinesin , KSP
TQ0318	Filanesib	ARRY-520,ARRY 520	KSP
	Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.		KSP
T9682	AZD-4877	AZD4877	Apoptosis , Kinesin
	AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and med...		Apoptosis , Kinesin
TQ0318L	ARRY 520 hydrochloride		KSP
	ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.		KSP
T2511	Plinabulin	NPI-2358	Microtubule Associated
	Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...		Microtubule Associated