Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 90.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 532.00 | |
50 mg | In stock | $ 769.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 253.00 |
Description | ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity. |
In vitro | ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1]. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors[1].ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells[1]. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2]. ARRY 520 is able to induce caspase-2 activation[3]. ARRY 520 is cytotoxic in Type II EOC cells[3]. |
In vivo | ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model[3]. |
Molecular Weight | 456.94 |
Formula | C20H23ClF2N4O2S |
CAS No. | 1385020-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.42 mM)
You can also refer to dose conversion for different animals. More
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ARRY 520 hydrochloride 1385020-40-5 Cell Cycle/Checkpoint KSP ARRY 520 Hydrochloride ARRY-520 Hydrochloride ARRY520 Hydrochloride inhibitor inhibit