Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.
Description | ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity. |
In vitro | ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1]. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors[1].ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells[1]. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2]. ARRY 520 is able to induce caspase-2 activation[3]. ARRY 520 is cytotoxic in Type II EOC cells[3]. |
In vivo | ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model[3]. |
Molecular Weight | 456.94 |
Formula | C20H23ClF2N4O2S |
CAS No. | 1385020-40-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (109.42 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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ARRY 520 hydrochloride 1385020-40-5 细胞周期 KSP Inhibitor inhibitor inhibit