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NMS-P715

Catalog No. T12237 CAS 1202055-32-0

NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).

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NMS-P715, CAS 1202055-32-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
2 mg	In stock	$ 98.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 486.00
50 mg	In stock	$ 716.00
100 mg	In stock	$ 987.00

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Purity: 98.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Targets&IC50	MELK:6.01 μM, CK2:5.7 μM, Mps1:182 nM, NEK6:6.02 μM
In vitro	NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1].
In vivo	NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1].

Molecular Weight	676.73
Formula	C35H39F3N8O3
CAS No.	1202055-32-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (2.96 mM), Sonication is recommended.

References and Literature

1. Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. 2. Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library MAPK Inhibitor Library Kinase Inhibitor Library Anti-Pancreatic Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compound Library Anti-Obesity Compound Library Preclinical Compound Library

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Related compounds with same targets

LY294002 TBB CK2α-IN-1 CKI-7 CKI-7 free base XL413 IWP-2 Casein kinase 1δ-IN-7

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NMS-P715 1202055-32-0 Cytoskeletal Signaling MAPK Metabolism PI3K/Akt/mTOR signaling Stem Cells MELK Casein Kinase Kinesin NMS-P 715 Monopolar spindle 1 Mps1 NMS P715 NMS-P-715 inhibit NMSP715 Inhibitor inhibitor

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