Shopping Cart
- Remove All
Your shopping cart is currently empty
NMS-P715
🥰Excellent
Catalog No. T12237Cas No. 1202055-32-0
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
NMS-P715
🥰Excellent
Purity: 98.41%
Catalog No. T12237Cas No. 1202055-32-0
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $72 | In Stock | |
| 2 mg | $98 | In Stock | |
| 5 mg | $155 | In Stock | |
| 10 mg | $247 | In Stock | |
| 25 mg | $486 | In Stock | |
| 50 mg | $716 | In Stock | |
| 100 mg | $987 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "NMS-P715"
CMPD1
T1498841179-33-3
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
- $31
Size
QTY
TBCA
Casein Kinase II Inhibitor III, TBCA
T21915934358-00-6In house
TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.
- $45
Size
QTY
Emodin
Cited
Frangula emodin
T2869518-82-1
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.
- $45
Size
QTY
CitedVemurafenib Cited
RO5185426, RG7204, PLX4032
T2382918504-65-1
Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive melanoma.
- $50
Size
QTY
CitedTakinib Cited
EDHS-206
T42641111556-37-6
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
- $66
Size
QTY
CitedLY294002
Cited
SF 1101, NSC 697286, LY 294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
- $34
Size
QTY
CitedRV01
T127811016897-10-1
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.
- $56
Size
QTY
sodium lauroyl-α-hydroxyethyl sulfonate
T7283112714-99-5
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
- $53
Size
QTY
LY-364947 Cited
LY 364947, HTS466284
T2048396129-53-6
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
- $59
Size
QTY
Cited
RMM46
T261031307896-46-3In house
RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.
- $293
Size
QTY
CitedSelect Batch
Purity:98.41%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). |
| Targets&IC50 | NEK6:6.02 μM, Mps1:182 nM, CK2:5.7 μM, MELK:6.01 μM |
| In vitro | NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1]. |
| In vivo | NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1]. |
| Molecular Weight | 676.73 |
| Formula | C35H39F3N8O3 |
| Cas No. | 1202055-32-0 |
| Smiles | CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21 |
| Relative Density. | 1.39 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (2.96 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
| |||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy NMS-P715 | purchase NMS-P715 | NMS-P715 cost | order NMS-P715 | NMS-P715 chemical structure | NMS-P715 in vivo | NMS-P715 in vitro | NMS-P715 formula | NMS-P715 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.