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NMS-P715

Catalog No. T12237 CAS 1202055-32-0

NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).

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NMS-P715, CAS 1202055-32-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Targets&IC50	MELK:6.01 μM, CK2:5.7 μM, Mps1:182 nM, NEK6:6.02 μM
In vitro	NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1].
In vivo	NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1].

Molecular Weight	676.73
Formula	C35H39F3N8O3
CAS No.	1202055-32-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2 mg/mL (2.96 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. 2. Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NMS-P715 1202055-32-0 MAPK信号通路 PI3K/Akt/mTOR信号通路代谢干细胞细胞骨架 Casein Kinase Kinesin MAPK MELK Monopolar spindle 1 Mps1 NMS P715 inhibit NMSP715 Inhibitor NMS-P-715 inhibitor

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