Powder: -20°C for 3 years
In solvent: -80°C for 2 years
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Description | NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). |
Targets&IC50 | MELK:6.01 μM, CK2:5.7 μM, Mps1:182 nM, NEK6:6.02 μM |
In vitro | NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1]. |
In vivo | NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1]. |
Molecular Weight | 676.73 |
Formula | C35H39F3N8O3 |
CAS No. | 1202055-32-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 2 mg/mL (2.96 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NMS-P715 1202055-32-0 MAPK信号通路 PI3K/Akt/mTOR信号通路 代谢 干细胞 细胞骨架 Casein Kinase Kinesin MAPK MELK Monopolar spindle 1 Mps1 NMS P715 inhibit NMSP715 Inhibitor NMS-P-715 inhibitor