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Empesertib

Catalog No. T8487 CAS 1443763-60-7

Synonyms: BAY 1161909

Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.

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Empesertib, CAS 1443763-60-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
Targets&IC50	Mps1:1 nM

Synonyms	BAY 1161909
Molecular Weight	559.62
Formula	C29H26FN5O4S
CAS No.	1443763-60-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. SCHULZE, Volker, et al. PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES. WO2014198647A2

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

EMD534085 Monastrol S-trityl-L-Cysteine BAY1217389 Dimethylenastron CFI-402257 TC-Mps1-12 Betamethasone 17-benzoate

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Empesertib 1443763-60-7 细胞骨架 Kinesin BAY-1161909 Inhibitor inhibit BAY 1161909 Mps1 BAY1161909 Monopolar spindle 1 inhibitor

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