sclerosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2315	Glatiramer Acetate		Others
	Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS).		Others
T4903	Heptadecanoic acid		Others , Endogenous Metabolite
	Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many "odd" length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% o...		Others , Endogenous Metabolite
T4283	SRI-011381		TGF-beta/Smad
	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T9125	Tolebrutinib	PRN2246,SAR442168	BTK
	Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi...		BTK
T9174	Icerguastat	Sephin 1,lcerguastat,IFB-088	Phosphatase
	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.		Phosphatase
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T6403	Siponimod	BAF-312	S1P Receptor , LPL Receptor
	BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi...		S1P Receptor , LPL Receptor
T6923	Ozanimod	RPC-1063	S1P Receptor , LPL Receptor
	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...		S1P Receptor , LPL Receptor
T0492	Dimethyl fumarate	DMF	Reactive Oxygen Species , HIV Protease , Nrf2 , Endogenous Metabolite , Autophagy
	Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
T39924	NF-κΒ activator 2		NF-κB
	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo...		NF-κB
T4031	S1p receptor agonist 1	S1p-receptor-agonist-1	S1P Receptor , LPL Receptor
	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.		S1P Receptor , LPL Receptor
T16079	Mirodenafil	SK3530	PDE
	Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.		PDE
T6561	Laquinimod	LAQ,ABR-215062	Apoptosis , Others , NF-κB
	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy.		Apoptosis , Others , NF-κB
T22911	β-N-methylamino-L-alanine hydrochloride	L-BMAA hydrochloride	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. L-BMAA hydrochloride could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases...		Others
T5129	SRI-011381 hydrochloride	SRI-011381 hydrochloride [1629138-41-5(free base)]	TGF-beta/Smad
	SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T2558	Cladribine	2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis , Adenosine deaminase
	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.		Apoptosis , Adenosine deaminase
TQ0126	Mirodenafil dihydrochloride	SK-3530 dihydrochloride	PDE
	Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.		PDE
T14219	Aminaftone	Aminaphthone	Endothelin Receptor
	Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.		Endothelin Receptor
T13553	Arimoclomol	BRX-220 free base	HSP
	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).		HSP
T3044	(E/Z)-Teriflunomide	Aubagio,HMR-1726,Flucyamide,A77 1726	Dehydrogenase
	(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.		Dehydrogenase