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Icerguastat

Catalog No. T9174 CAS 951441-04-6

Synonyms: Sephin 1, lcerguastat, IFB-088

Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

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Icerguastat, CAS 951441-04-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 51.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 289.00
200 mg	In stock	$ 428.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.67%

Biological Description

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Description	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.
In vitro	Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein[1].
In vivo	In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged[1].

Synonyms	Sephin 1, lcerguastat, IFB-088
Molecular Weight	196.64
Formula	C8H9ClN4
CAS No.	951441-04-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL(1017.10 mM), Sonication is recommended.

References and Literature

1. Thapa S , Abdelaziz D H , Abdulrahman B A , et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model[J]. Molecular Neurobiology, 2020, 57(4542).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Preclinical Compound Library Phosphatase Inhibitor Library Bioactive Compounds Library Max Glycometabolism Compound Library Endoplasmic Reticulum Stress Compound Library Clinical Compound Library NO PAINS Compound Library Anti-Infection Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Icerguastat 951441-04-6 Metabolism Phosphatase Sephin1 Inhibitor IFB088 misfolding Sephin-1 prion IFB 088 stress eIF2α sclerosis Sephin 1 inhibit lcerguastat IFB-088 protein inhibitor

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