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(E/Z)-Teriflunomide

Catalog No. T3044 CAS 108605-62-5

Synonyms: Aubagio, HMR-1726, Flucyamide, A77 1726

(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(E/Z)-Teriflunomide, CAS 108605-62-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 50.00
50 mg	In stock	$ 57.00
100 mg	In stock	$ 74.00
200 mg	In stock	$ 97.00

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Purity: 99.76%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
In vitro	In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in female Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation.
In vivo	Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibiting the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly proliferative T and B lymphocytes, Teriflunomide effectively reduces the inflammatory response to self-antigens.

Synonyms	Aubagio, HMR-1726, Flucyamide, A77 1726
Molecular Weight	270.21
Formula	C12H9F3N2O2
CAS No.	108605-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27 mg/mL (100 mM)

References and Literature

1. Oh J, et al. Ther Clin Risk Manag. 2013;9:177-90. doi: 10.2147/TCRM.S30947. Epub 2013 Apr 26.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library FDA-Approved Drug Library Anti-Cancer Metabolism Compound Library Fluorochemical Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Drug-induced Liver Injury (DILI) Compound Library Drug-Fragment Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(E/Z)-Teriflunomide 108605-62-5 Metabolism Dehydrogenase Teriflunomide HMR1726 Aubagio HMR-1726 Flucyamide A77 1726 HMR 1726 inhibitor inhibit

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