reticulum — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38831	Endoplasmic reticulum dye 1
	Endoplasmic reticulum dye 1 is a highly effective live cell imaging agent used for detecting exocytotic events occurring at the plasma membrane. This compound exhibits minimal cytotoxicity and is resistant to photobleach...
T2614	GSK2606414		Apoptosis , PERK , Autophagy
	GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).		Apoptosis , PERK , Autophagy
T2654	GSK2656157		Apoptosis , PERK , Autophagy
	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 kinases.		Apoptosis , PERK , Autophagy
T21976	ONO-8130		Prostaglandin Receptor
	ONO-8130 is an orally available antagonist of EP1 receptor.		Prostaglandin Receptor
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T11221	ERAP1-IN-1		Others
	ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activi...		Others
T8982	RH01687		Others
	RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.		Others
T6183	ISRIB (trans-isomer)	ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis , PERK , Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).		Apoptosis , PERK , Autophagy
T9110	Ceapin-A7		Others
	Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.		Others
T9349	IXA4		IRE1
	IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.		IRE1
T8901	YUM70		Apoptosis , GPR , HSP
	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate...		Apoptosis , GPR , HSP
T16873	SERCA2a activator 1		Calcium Channel
	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.		Calcium Channel
T5A2461	Bufotalin	Bufotaline	Apoptosis , Others , Reactive Oxygen Species
	1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.		Apoptosis , Others , Reactive Oxygen Species
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T1198	Tetracaine hydrochloride	Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel , Sodium Channel
	Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use...		Calcium Channel , Sodium Channel
T19663	Triheptanoin	UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011	Others
	Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1.		Others
T0787	Butylhydroxyanisole	BHA,E320,Butylated hydroxyanisole	Antioxidant , Ferroptosis , Reactive Oxygen Species
	Butylhydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.		Antioxidant , Ferroptosis , Reactive Oxygen Species
T2532	Tauroursodeoxycholate	Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode...		Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
T6993	Tauroursodeoxycholate sodium	Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis , ERK , Caspase
	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.		Apoptosis , ERK , Caspase