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ONO-8130

Catalog No. T21976 CAS 459841-96-4

ONO-8130 is an orally available antagonist of EP1 receptor.

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ONO-8130, CAS 459841-96-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 162.00
5 mg	In stock	$ 360.00
10 mg	In stock	$ 593.00
25 mg	In stock	$ 948.00
50 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 481.00

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Purity: 97.82%

Biological Description

Chemical Properties

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Description

ONO-8130 is an orally available antagonist of EP1 receptor.

In vivo

Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1].

Molecular Weight	500.63
Formula	C25H28N2O5S2
CAS No.	459841-96-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (10 mM)

References and Literature

1. Miki T , Matsunami M , Nakamura S , et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis.[J]. Pain, 2011, 152(6):1373-1381. 2. Baker S , Kraak G . Investigating the role of prostaglandin receptor isoform EP4b in zebrafish ovulation[J]. General and Comparative Endocrinology, 2019, 283:113228.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Immunology/Inflammation Compound Library Orally Active Compound Library Preclinical Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library

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Keywords

ONO-8130 459841-96-4 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Orally active Inhibitor inhibit Bladder pain Interstitial cystitis PKR-like endoplasmic reticulum kinase PERK Hyperalgesia Protein kinase R-like endoplasmic reticulum kinase ONO8130 ONO 8130 inhibitor

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