reporter — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23383	SR11237	SR 11237	Others , RAR/RXR
	SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.		Others , RAR/RXR
T4043	ETC-159	ETC159,ETC-1922159,ETC 159	Wnt/beta-catenin , Porcupine
	ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.		Wnt/beta-catenin , Porcupine
T24729	Roseoflavin		Antibacterial
	Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis.		Antibacterial
T22101	ML-031		S1P Receptor
	ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.		S1P Receptor
T22818	GSK9027	GR agonist 23a,GSK 9027,GSK-9027	Glucocorticoid Receptor
	GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity.		Glucocorticoid Receptor
T14038L	4-Azido-L-phenylalanine hydrochloride	p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride	Others
	4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) is an unnatural amino acid used as an effective vibrational reporter of local protein environments.		Others
T15677	KY1220		Wnt/beta-catenin
	KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.		Wnt/beta-catenin
T19850	Semaglutide		Glucagon Receptor
	Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).		Glucagon Receptor
T4339	YU238259		DNA-PK , Others
	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.		DNA-PK , Others
T4361	CBL0137 hydrochloride	CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride	Others , NF-κB , p53
	CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT.		Others , NF-κB , p53
TN7236	Cephalandole B		IL Receptor
	cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner.		IL Receptor
T6808	Coelenterazine	Oplophorus luciferin,Coelenteramine	Others
	Coelenterazine (Coelenteramine) is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.		Others
T4684	ML241 hydrochloride		p97
	ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemo...		p97
T8752	BAR 501 impurity		GPCR19
	BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act...		GPCR19
T36527	IL-4-inhibitor-1		IL Receptor
	IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib...		IL Receptor
T37587	ML 209		ROR
	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM...		ROR
T4687	Ro5-3335	CBFβ-Runx1 inhibitor II,Ro 5-3335	DNA/RNA Synthesis
	Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ...		DNA/RNA Synthesis
T36587	8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt		Others
	8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively. It forms a ground state complex with viologen-type quenchers, inducing a red-shift i...		Others
T38238	2'-Deoxy-2'-fluorocytidine		Nucleoside Antimetabolite/Analog , Influenza Virus
	2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency o...		Nucleoside Antimetabolite/Analog , Influenza Virus
T13067	TAK-828F		ROR
	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).		ROR